Tumor Necrosis Factor Ligand Superfamily Member 18, active (TNFSF18), Recombinant, Human

Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1 (PubMed:23892569). Promotes leukocyte adhesion to endothelial cells (PubMed:23892569). Regulates migration of monocytes from the splenic reservoir to sites of inflammation (By similarity). {ECO:0000250, UniProtKB:Q7TS55, ECO:0000269, PubMed:17449724, ECO:0000269, PubMed:18040044, ECO:0000269, PubMed:23892569}. Biological Activity: Fully biologically active when compared to standard. The biological activity as determined by stimulation of IL-8 production using human PBMC is in a concentration range of 0.1-10ng/ml. Sequence: ETAKEPCMAK FGPLPSKWQM ASSEPPCVNK VSDWKLEILQ NGLYLIYGQV APNANYNDVA PFEVRLYKNK DMIQTLTNKS KIQNVGGTYE LHVGDTIDLI FNSEHQVLKN NTYWGIILLA NPQFIS, Molecular Weight: 14.3kD, PubMed ID: 16710414, 15489334, 14702039, 12975309, 10074428, 10037686, 17449724, 23892569, 18040044, Gene Name: TNFSF18,AITRL,GITRL,TL6,UNQ149/PRO175, Swiss Prot: Q9UNG2, Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.