TSLP, Recombinant, Mouse, aa20-140, His-Tag

TSLP, also known as thymic stromal lymphopoietin, is a protein belonging to the cytokine family. This protein plays an important role in the maturation of T cell populations through activation of antigen presenting cells. It is an interleukin 7-like cytokine originally characterized by its ability to promote the activation of B cells and dendritic cells (DCs). It is expressed by non-hematopoietic cells such as fibroblasts, epithelial, cells and different types of stromal or stromal-like cells, and is important in allergic inflammation. It signals through a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor CRLF2 and the IL-7R alpha chain. After binding STAT5 phosphorylation is induced resulting in the expression of upstream transcription factors. Also, expression of TSLP is linked to many disease states including asthma, inflammatory arthritis, atopic dermatitis, eczema, eosinophilic esophagitis and other allergic states. but the factors are not clearly defined. Source: Recombinant protein corresponding to aa20-140 from mouse TSLP fused to His-Tag at C-terminal expressed in Baculovirus. Molecular Weight: ~15.0kD (130aa), Endotoxin: ~1EU/1ug (LAL), AA Sequence: ADPYNFSNCN FTSITKIYCN IIFHDLTGDL KGAKFEQIED CESKPACLLK IEYYTLNPIP GCPSLPDKTF ARRTREALND HCPGYPETER NDGTQEMAQE VQNICLNQTS QILRLWYSFM QSPEHHHHHH, Applications: Suitable for use in SDS-PAGE. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 6 months after receipt at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.