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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
010-001-W23-0100 | 100 µg | - | - |
6 - 10 business days* |
891.00€
|
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Stromal Cell-Derived Factor-1 beta (CXCL12) purity was determined to be greater than 97% as... more
Product information "Stromal Cell-Derived Factor-1 beta (CXCL12)"
Stromal Cell-Derived Factor-1 beta (CXCL12) purity was determined to be greater than 97% as determined by HpLC, analysis by UV-Spectroscopy at 280nm, and by reducing and non-reducing SDS-pAGE. Protein function: Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T- lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of ACKR3 expressed in various cells. Has several critical functions during embryonic development, required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation. [The UniProt Consortium]
Keywords: | Sdf1, PBSF, TLSF, TPAR1, SDF-1, Cxcl12, C-X-C motif chemokine 12, Stromal cell-derived factor 1, Pre-B cell growth-stimulating factor, Thymic lymphoma cell-stimulating factor, 12-O-tetradecanoylphorbol 13-acetate repressed protein 1 |
Supplier: | Rockland Immunochemicals |
Supplier-Nr: | 010-001-W23-0100 |
Properties
Application: | Cell culture |
Conjugate: | No |
Host: | E.coli |
Species reactivity: | mouse |
Database Information
KEGG ID : | K10031 | Matching products |
UniProt ID : | P40224 | Matching products |
Gene ID | GeneID 20315 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +20°C (International: +20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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