Cookie preferences
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the comfort when using this website, are used for direct advertising or to facilitate interaction with other websites and social networks, are only set with your consent.
Configuration
Technically required
These cookies are necessary for the basic functions of the shop.
"Allow all cookies" cookie
"Decline all cookies" cookie
CSRF token
Cookie preferences
Currency change
Customer-specific caching
FACT-Finder tracking
Individual prices
Selected shop
Session
Comfort functions
These cookies are used to make the shopping experience even more appealing, for example for the recognition of the visitor.
Note
Show the facebook fanpage in the right blod sidebar
Statistics & Tracking
Affiliate program
Conversion and usertracking via Google Tag Manager
Track device being used
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay31849-100 | 100 µg | - |
6 - 10 business days* |
86.00€
|
|||
Cay31849-1 | 1 mg | - |
6 - 10 business days* |
300.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Leptin is a peptide hormone that regulates energy homeostasis, growth, and reproduction, as well... more
Product information "Leptin (human, recombinant)"
Leptin is a peptide hormone that regulates energy homeostasis, growth, and reproduction, as well as immune function. It is secreted by adipocytes and regulated by nutritional status, where fasting reduces leptin levels and feeding increases leptin levels, as well as in a circadian manner, with serum levels peaking at night. Circulating leptin can bind leptin receptors expressed by peripheral immune cells, such as macrophages, natural (NK) cells, and B and T cells, or be transported across the blood brain barrier, where it binds to neuronally expressed leptin receptors. Binding of leptin to the leptin receptor induces the recruitment and phosphorylation of JAK2, leading to activation of a variety of intracellular signaling cascades, including MAPK-, STAT-, PI3K-, and AMPK-mediated pathways. Leptin-dependent signaling pathways promote energy expenditure, growth, and reproductive functions, reduce food intake and the production of adrenal corticosteroids, and enhance innate and adaptive immune responses. Leptin-deficient ob/ob mice exhibit severe obesity, hyperlipidemia, hyperglycemia, and hyperinsulinemia and are a commonly used model of obesity and type 2 diabetes. Serum leptin levels are increased in individuals with a variety of conditions, including obesity or insulin resistance. Cayman's Leptin (human, recombinant) protein can be used for binding assays. The protein was synthesized from a DNA sequence encoding the mature form of human leptin (Val22-Cys167) with an N-terminal translation-initiating methionine (Met1). The expressed protein consists of 147 amino acids, has a calculated molecular weight of 16 kDa, and a predicted N-terminus of Met1.Synonyms: LEPD, Obesity Factor, OBS. Purity: >98% estimated by SDS-PAGE. Source: Active recombinant human leptin expressed in E. coli. Amino Acids: Met1, 22-167. MW: 16 kDa. Formulation: (Request formulation change), Lyophilized from sterile PBS, pH 7.4. UniProt Accession #: P41159.
Keywords: | Obese protein, Obese protein, Obesity factor, Obesity factor, Leptin {ECO:0000312|HGNC:HGNC:6553}, Leptin {ECO:0000312|HGNC:HGNC:6553} |
Supplier: | Cayman Chemical |
Supplier-Nr: | 31849 |
Properties
Application: | Active, Cell culture |
Conjugate: | No |
Host: | E.coli |
Purity: | >98% estimated by SDS-PAGE |
Format: | Lyophilized |
Database Information
KEGG ID : | K05424 | Matching products |
UniProt ID : | P41159 | Matching products |
Gene ID | GeneID 3952 | Matching products |
Handling & Safety
Storage: | -80°C |
Shipping: | -80°C (International: -80°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
more
You will get a certificate here
Viewed