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Interleukin-4, HEK, human recombinant (rHuIL-4-HEK)
Product information "Interleukin-4, HEK, human recombinant (rHuIL-4-HEK)"
Human recombinant IL-4 produced in HEK cells is a glycosylated monomer, having a molecular weight range of 14-19kDa due to glycosylation. IL-4 is a pleiotropic cytokine produced by activated T cells. IL-4 is a ligand for interleukin-4 receptor. The interleukin-4 receptor also binds to IL-13, which may contribute to many overlapping functions of this cytokine and IL-13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL-3, IL-5, IL-13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL-13. IL-4, IL-13 and IL-5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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