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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
E-PKSH033284.10 | 10 µg | - |
7 - 16 business days* |
212.00€
|
|||
E-PKSH033284.50 | 50 µg | - |
7 - 16 business days* |
622.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein Construction: Recombinant Human Interleukin-12 is produced by our Mammalian expression... more
Product information "Interleukin-12 Protein (recombinant human)"
Protein Construction: Recombinant Human Interleukin-12 is produced by our Mammalian expression system and the target gene encoding Arg23-Ser219&Ile23-Ser328 is expressed. Sequence: Arg23-Ser219&Ile23-Ser328. Endotoxin: < 1.0 EU per µg as determined by the LAL method. Apparent Molecular Mass: 40-50 kDa. Protein function: IL-12 is a heterodimeric pleiotropic cytokine made up of a 40 kDa (p40) subunit and a 35 kDa (p35) subunit.Human and mouse IL-12 share 70% and 60% amino acid sequence identity in their p40 and p35 subunits, respectively. IL-12 is involved in the differentiation of naive T cells into Th1 cells. It is known as a T cell-stimulating factor, which can stimulate the growth and function of T cells. It stimulates the production of interferon-gamma (IFN-?) and tumor necrosis factor-alpha (TNF-a) from T cells and natural killer (NK) cells, and reduces IL-4 mediated suppression of IFN-?. T cells that produce IL-12 have a coreceptor, CD30, which is associated with IL-12 activity.IL-12 plays an important role in the activities of natural killer cells and T lymphocytes. IL-12 mediates enhancement of the cytotoxic activity of NK cells and CD8+ cytotoxic T lymphocytes. Protein function: Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine- activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. [The UniProt Consortium]
Keywords: | NKSF2, IL12B, IL-12B, CLMF p40, IL-12 subunit p40, Interleukin-12 subunit beta, NK cell stimulatory factor chain 2, Cytotoxic lymphocyte maturation factor 40 kDa subunit, Recombinant Human Interleukin-12 Protein |
Supplier: | Elabscience |
Supplier-Nr: | E-PKSH033284 |
Properties
Conjugate: | No |
Host: | Human cells |
Species reactivity: | human |
MW: | 22.5 kD |
Format: | Lyophilized |
Database Information
KEGG ID : | K05425 | Matching products |
UniProt ID : | P29460 | Matching products |
Gene ID | GeneID 3593 | Matching products |
Handling & Safety
Storage: | -80°C |
Shipping: | +4°C (International: +20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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