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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
348087.5 | 5 µg | - | - |
3 - 19 business days* |
454.00€
|
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the... more
Product information "Interferon lambda-1, active (IFNL1), Recombinant, Human"
Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression. Biological Activity: Fully biologically active when compared to standard. The ED50 as determined by an anti-viral assay using human HepG2 cells infected with encephalomyocarditis is less than 5ng/ml, corresponding to a specific activity of ? 2.0x10e5 IU/mg. Sequence: GPVPTSKPTT TGKGCHIGRF KSLSPQELAS FKKARDALEE SLKLKNWSCS SPVFPGNWDL RLLQVRERPV ALEAELALTL KVLEAAAGPA LEDVLDQPLH TLHHILSQLQ ACIQPQPTAG PRPRGRLHHW LHRLQEAPKK ESAGCLEASV TFNLFRLLTR DLKYVADGNL CLRTSTHPES T, Molecular Weight: 19.8kD, PubMed ID: 12469119, 12483210, 15057824, 15489334, 20712453, 24751921, 20934432, Gene Name: IFNL1,IL29,ZCYTO21, Swiss Prot: Q8IU54, Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Keywords: | IL29, IL-29, IFNL1, IFN-lambda-1, Interleukin-29, Cytokine Zcyto21, Interferon lambda-1 |
Supplier: | United States Biological |
Supplier-Nr: | 348087 |
Properties
Conjugate: | No |
MW: | 19,8 |
Format: | Highly Purified |
Database Information
KEGG ID : | K05447 | Matching products |
UniProt ID : | Q8IU54 | Matching products |
Gene ID | GeneID 282618 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: °C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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