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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
E-PKSH033859.10 | 10 µg | - |
7 - 16 business days* |
192.00€
|
|||
E-PKSH033859.50 | 50 µg | - |
7 - 16 business days* |
578.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein Construction: Recombinant Chimeric Human&Mouse Interleukin-23 is produced by our... more
Product information "IL-23 alpha & Mouse IL-12 beta Heterodimer (C-6His) (recombinant human)"
Protein Construction: Recombinant Chimeric Human&Mouse Interleukin-23 is produced by our Mammalian expression system and the target gene encoding Arg20-Pro189&Met23-Ser335 is expressed with a 6His tag at the C-terminus. Sequence: Arg20-Pro189&Met23-Ser335. Fusion tag: C-6His Endotoxin: < 1.0 EU per µg as determined by the LAL method. Apparent Molecular Mass: 65-80 kDa. Protein function: Interleukin 23 (IL-23) is a heterodimeric cytokine composed of two disulfide-linked subunits, a p19 subunit that is unique to IL-23, and a p40 subunit that is shared with IL-12. The p19 subunit has homology to the p35 subunit of IL-12, as well as to other single chain cytokines such as IL-6 and IL-11. The p40 subunit is homologous to the extracellular domains of the hematopoietic cytokine receptors. Although p19 is expressed by activated macrophages, dendritic cells, T cells, and endothelial cells, only activated macrophages and dendritic cells express p40 concurrently to produce IL-23. IL-23 has biological activities that are similar to, but distinct from IL-12. Both IL-12 and IL-23 induce proliferation and IFN-gamma production by human T cells. While IL-12 acts on both naive and memory human T cells, the effects of IL-23 is restricted to memory T cells. Protein function: Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis. [The UniProt Consortium]
Keywords: | SGRF, IL23A, IL-23-A, IL-23p19, IL-23 subunit alpha, Interleukin-23 subunit p19, Interleukin-23 subunit alpha, Recombinant Human IL-23 alpha & Mouse IL-12 beta Heterodimer (C-6His) |
Supplier: | Elabscience |
Supplier-Nr: | E-PKSH033859 |
Properties
Conjugate: | No |
Host: | Human cells |
Species reactivity: | human |
MW: | 56.9 kD |
Format: | Lyophilized |
Database Information
KEGG ID : | K05426 | Matching products |
UniProt ID : | Q9NPF7 | Matching products |
Gene ID | GeneID 51561 | Matching products |
Handling & Safety
Storage: | -80°C |
Shipping: | 4°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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