FN14 (human):Fc (human, rec.)

(3 x 50µg). The extracellular region of human FN14 (amino acids 28-75) is fused at the C-terminus to the Fc portion of human IgG1. Lyophilized. Contains PBS. TWEAK is a cytokine that controls proliferation, migration, differentiation, apoptosis, angiogenesis and inflammation. TWEAK binds to Fn14, a highly inducible cell-surface receptor that is linked to several intracellular signalling pathways, including the nuclear factor-B (NF-kappaB) pathway. The TWEAK-Fn14 axis plays a beneficial role in tissue repair following acute injury and may contribute to cancer, chronic autoimmune diseases and acute ischaemic stroke.