TNF Ligand Receptor Superfamily Member 12A, human recombinant (rHuTNFRSF12A)

TNF Ligand Receptor Superfamily Member 12A, human recombinant (rHuTNFRSF12A)
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Item number Size Datasheet Manual SDS Delivery time Quantity Price
97573.5 5 µg - -

3 - 10 business days*

70.00€
97573.25 25 µg - -

3 - 10 business days*

180.00€
97573.1 1 mg - -

3 - 10 business days*

-
 
Human recombinant TNFRSF12A produced in E.coli is a single, non-glycosylated, polypeptide chain... more
Product information "TNF Ligand Receptor Superfamily Member 12A, human recombinant (rHuTNFRSF12A)"
Human recombinant TNFRSF12A produced in E.coli is a single, non-glycosylated, polypeptide chain containing 53 amino acids and having a molecular mass of 5.6 KDa. The gene for TNFRSF12A was initially recognized as a fibroblast growth factor inducible immediate early response gene Fn14 in mouse NIH 3T3 fibroblasts. Human TNFRSF12A cDNA encodes a 129 amino acid residue type I transmembrane protein with a 27 aa signal peptide, a 53 aa extracellular domain, a 21 aa transmembrane domain and a 28 aa cytoplasmic domain. Human and mouse TNFRSF12A hold 82% aa sequence identity. TNFRSF12 is the tiniest member of the TNF receptor superfamily and has only one cysteine rich region in its extracellular domain. The TNFRSF12A cytoplasmic domain holds one TRAF binding motif which binds TRAFs 1, 2, and 3. TNFRSF12A binds its ligand TWEAK/TNFSF12A with high affinity to initiate a signal transduction cascade which subject to the cell type, causes different cellular responses such as cell death, cell proliferation, and angiogenesis.
Keywords: Tumor necrosis factor receptor superfamily member 12A, FN14, CD266 antigen, TweakR, tweak-receptor, Fibroblast growth factor-inducible immediate-early response protein 14, FGF-inducible 14, type I transmembrane protein Fn14.
Supplier: Biomol GmbH
Supplier-Nr: 97573.1

Properties

Application: Cell Culture
Conjugate: No
Expressed in: E.coli
Origin: Human
MW: 5600 D
Purity: >97%
Format: Lyophilized

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: +20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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