Tumor Necrosis Factor Receptor Superfamily Member 12A, active (TNFRSF12A), Recombinant, Human

Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins. {ECO:0000269, PubMed:11728344}. Biological Activity: Fully biologically active when compared to standard. The ED50 as determined by inhibiting TWEAK- dependent proliferation of human umbilical vein endothelial cells (HUVEC) is less than 30ng/ml, corresponding to a specific activity of ? 3.3x10e4 IU/mg, in the presence of 15ng/ml of rHuTWEAK. Sequence: EQAPGTAPCS RGSSWSADLD KCMDCASCRA RPHSDFCLGC AAAPPAPFRL LWP, Molecular Weight: 5.6kD, PubMed ID: 10751351, 15489334, 11728344, 19241374, Gene Name: TNFRSF12A,FN14, Swiss Prot: Q9NP84, Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.