SN-38-d3

SN-38-d3 is intended for use as an internal standard for the quantification of SN-38 (Cay-15632) by GC- or LC-MS. SN-38 is an inhibitor of topoisomerase I and an active metabolite of the prodrug irinotecan (Cay-14180). It is formed from irinotecan by carboxylesterases. SN-38 (0.1, 1, and 10 µM) induces topoisomerase I-dependent DNA cleavage in a cell-free assay. It induces DNA single-strand breaks in HT-29 colorectal adenocarcinoma cells when used at a concentration of 200 nM and cytotoxicity in HT-29 cells (IC50 = 8.8 nM). SN-38 (100 mg/kg per day) reduces tumor volume without affecting body weight in an MX-1 breast cancer mouse xenograft model.Formal Name: 4-ethyl-11-(ethyl-2,2,2-d3)-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione. CAS Number: 718612-49-8. Synonyms: 7-Ethyl-10-Hydroxycamptothecin-d3, 7-ethyl-10-hydroxy-20(S)-Camptothecin-d3. Molecular Formula: C22H17D3N2O5. Formula Weight: 395.4. Purity: >99% deuterated forms (d1-d3). Formulation: (Request formulation change), A solid. Solubility: DMSO: Slightly soluble, Methanol: Slightly soluble. SMILES: O=C([C@]1(O)CC)OCC2=C1C=C(C(N=C(C=CC(O)=C3)C3=C4CC([2H])([2H])[2H])=C4C5)N5C2=O. InChi Code: InChI=1S/C22H20N2O5/c1-3-12-13-7-11(25)5-6-17(13)23-19-14(12)9-24-18(19)8-16-15(20(24)26)10-29-21(27)22(16,28)4-2/h5-8,25,28H,3-4,9-10H2,1-2H3/t22-/m0/s1/i1D3. InChi Key: FJHBVJOVLFPMQE-MVTYLIICSA-N.