Etomidate-d5

Etomidate-d5 is intended for use as an internal standard for the quantification of etomidate by GC- or LC-MS. Etomidate is a general anesthetic. It selectively binds to GABAA receptors over voltage-gated sodium channels (Nav) and L-type voltage-gated calcium channels (Cav, IC50s = 15.7, 387, and 950 µM, respectively). Etomidate also inhibits the cytochrome P450 (CYP) isoforms CYP11B1 and CYP11B2 (IC50s = 0.5 and 0.1 nM, respectively), enzymes involved in cortisol and aldosterone biosynthesis, respectively. It inhibits the production of deoxycortisol and 17alpha-hydroxy progesterone (Cay-33154) induced by adrenocorticotropic hormone (ACTH) in dispersed adrenocortical cells isolated from patients with Cushing's syndrome. Etomidate (3 mg/kg) induces anesthesia and increases the minimum convulsive dose of pentylenetetrazole during the recovery period, but also induces myoclonus, in mice. Formulations containing etomidate have been used as general anesthetics.Formal Name: 1-[(1R)-1-(phenyl-d5)ethyl]1H-imidazole-5-carboxylic acid ethyl ester. Synonyms: (+)-Etomidate-d5, d-Etomidate-d5, (R)-Etomidate-d5. Molecular Formula: C14H11D5N2O2. Formula Weight: 249.3. Purity: >99% deuterated forms (d1-d5). Formulation: (Request formulation change), A neat liquid. Solubility: DMF: soluble, DMSO: soluble, Ethanol: soluble, Methanol: soluble. SMILES: O=C(OCC)C1=CN=CN1[C@H](C)C2=C([2H])C([2H])=C([2H])C([2H])=C2[2H]. InChi Code: InChI=1S/C14H16N2O2/c1-3-18-14(17)13-9-15-10-16(13)11(2)12-7-5-4-6-8-12/h4-11H,3H2,1-2H3/t11-/m1/s1/i4D,5D,6D,7D,8D. InChi Key: NPUKDXXFDDZOKR-IYMQPUKBSA-N.