221 products were found matching "K05175"!

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse gABRa2. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse gABRa2....

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human gABRa2. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human gABRa2....

Progabide is a GABA receptor agonist. It selectively binds to the GABAA and GABAB receptors in postmortem rat cortical membranes (IC50s = 35 and 100 µM, respectively) over alpha- and beta-adrenergic, dopamine, serotonin, histamine H1, and muscarinic receptors (IC50s = >100 µM) in radioligand binding assays....

alpha-hydroxy Triazolam-13C2-d4 (CRM) (Cay-43154) is intended for use as an internal standard for the quantification of alpha-hydroxy triazolam (Cay-40187, Cay-39390) by GC- or LC-MS. alpha-hydroxy Triazolam is categorized as a benzodiazepine. It is an active metabolite of triazolam (Cay-39683, Cay-22577). It has...

N-Desmethyladinazolam (Cay-43383) is an analytical reference standard categorized as a benzodiazepine. N-Desmethyladinazolam is a metabolite of adinazolam (Cay-30186, Cay-18205). This product is intended for research and forensic applications. Synonyms: Mono-N-Demethyladinazolam NDMAD U-42352. Formal Name:...

Etomidate-d5 (Cay-44952) is intended for use as an internal standard for the quantification of etomidate (Cay-41826, Cay-21993) by GC- or LC-MS. Etomidate is categorized as an anesthetic. Etomidate has been associated with overdose and death. Formulations containing etomidate have been used as anesthetics. This...

Flumazenil is a GABAA receptor antagonist (IC50 = 2 nM in a radioligand binding assay using rat cortical synaptosomes). Flumazenil also acts as a partial agonist of GABAA receptors, decreasing the amplitude of electrically stimulated population spikes in rat hippocampal CA1 pyramidal neurons. It increases the number...

Avermectin B1a is a macrocyclic lactone disaccharide anthelmintic agent that binds to high and low affinity sites on the mammalian GABAA receptor. Binding to the high affinity site activates the receptor to increase chloride influx, while binding to the low affinity site blocks the channel. Avermectin B1a inhibits...

SAGE-217 is a positive allosteric modulator of GABAA receptors. It potentiates GABA-induced currents in LTK cells expressing alpha4beta2gamma2 subunit-containing GABAA receptors and CHO cells expressing alpha4beta3delta subunit-containing GABAA receptors (EC50s = 375 and 299 nM, respectively). SAGE-217 (0.3-10...

TP-003 is a positive allosteric modulator of the GABAA receptor (GABAAR). It potentiates GABA-induced currents in HEK293 cells expressing alpha1beta2gamma2, alpha2beta3gamma2, alpha3beta3gamma2, or alpha5beta2gamma2 subunit-containing GABAARs (EC50s = 20. 10. 3. and 5. nM, respectively). TP-003 (10 mg/kg) increases...

3alpha,5alpha-THDOC is a neurosteroid and positive allosteric modulator of GABAA receptors. It inhibits binding of the convulsant t-butylbicyclophosphorothionate (TBPS) and increases binding of the benzodiazepine flunitrazepam to rat synaptosomal membrane preparations in a concentration-dependent manner....

Pentylenetetrazole (PTZ) is a central nervous system modulator that is used to experimentally induce seizures in animals. Subcutaneous PTZ has been used extensively to screen for compounds that block the production of nonconvulsive (absence or myoclonic) seizures. PTZ has diverse, site-specific effects in the brain....