210 products were found matching "K05175"!

alpha-hydroxy Triazolam-13C2-d4 (CRM) (Cay-43154) is intended for use as an internal standard for the quantification of alpha-hydroxy triazolam (Cay-40187, Cay-39390) by GC- or LC-MS. alpha-hydroxy Triazolam is categorized as a benzodiazepine. It is an active metabolite of triazolam (Cay-39683, Cay-22577). It has...

N-Desmethyladinazolam (Cay-43383) is an analytical reference standard categorized as a benzodiazepine. N-Desmethyladinazolam is a metabolite of adinazolam (Cay-30186, Cay-18205). This product is intended for research and forensic applications. Synonyms: Mono-N-Demethyladinazolam NDMAD U-42352. Formal Name:...

Etomidate-d5 (Cay-44952) is intended for use as an internal standard for the quantification of etomidate (Cay-41826, Cay-21993) by GC- or LC-MS. Etomidate is categorized as an anesthetic. Etomidate has been associated with overdose and death. Formulations containing etomidate have been used as anesthetics. This...

SAGE-217 is a positive allosteric modulator of GABAA receptors. It potentiates GABA-induced currents in LTK cells expressing alpha4beta2gamma2 subunit-containing GABAA receptors and CHO cells expressing alpha4beta3delta subunit-containing GABAA receptors (EC50s = 375 and 299 nM, respectively). SAGE-217 (0.3-10...

TP-003 is a positive allosteric modulator of the GABAA receptor (GABAAR). It potentiates GABA-induced currents in HEK293 cells expressing alpha1beta2gamma2, alpha2beta3gamma2, alpha3beta3gamma2, or alpha5beta2gamma2 subunit-containing GABAARs (EC50s = 20. 10. 3. and 5. nM, respectively). TP-003 (10 mg/kg) increases...

7-Aminoclonazepam-d4 (CRM) (Cay-42483) is intended for use as an internal standard for the quantification of 7-aminoclonazepam (Cay-20225) by GC- or LC-MS. 7-Aminoclonazepam is categorized as a benzodiazepine. It is a metabolite of clonazepam (Cay-ISO60181, Cay-14263). This product is intended for research and...

Flumazenil is a GABAA receptor antagonist (IC50 = 2 nM in a radioligand binding assay using rat cortical synaptosomes). Flumazenil also acts as a partial agonist of GABAA receptors, decreasing the amplitude of electrically stimulated population spikes in rat hippocampal CA1 pyramidal neurons. It increases the number...

Avermectin B1a is a macrocyclic lactone disaccharide anthelmintic agent that binds to high and low affinity sites on the mammalian GABAA receptor. Binding to the high affinity site activates the receptor to increase chloride influx, while binding to the low affinity site blocks the channel. Avermectin B1a inhibits...

3alpha,5alpha-THDOC is a neurosteroid and positive allosteric modulator of GABAA receptors. It inhibits binding of the convulsant t-butylbicyclophosphorothionate (TBPS) and increases binding of the benzodiazepine flunitrazepam to rat synaptosomal membrane preparations in a concentration-dependent manner....

Pentylenetetrazole (PTZ) is a central nervous system modulator that is used to experimentally induce seizures in animals. Subcutaneous PTZ has been used extensively to screen for compounds that block the production of nonconvulsive (absence or myoclonic) seizures. PTZ has diverse, site-specific effects in the brain....

Rilmazolam (Cay-39863) is an analytical reference standard categorized as a triazolobenzodiazepine. Rilmazolam is an active metabolite of rilmazafone. This product is intended for research and forensic applications.Formal Name:...

Protein function: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. [The UniProt Consortium]