Buspirone-d8 (hydrochloride)

Buspirone-d8 is intended for use as an internal standard for the quantification of buspirone by GC- or LC-MS. Buspirone is a partial agonist of the serotonin (5-HT) receptor subtype 5-HT1A. It binds to the 5-HT1A receptor (IC50 = 5.6 nM) and inhibits forskolin-induced adenylate cyclase activity in primary CA1 hippocampal pyramidal cells. Buspirone inhibits conditioned avoidance responding in rats, as well as inhibits foot shock-induced fighting in mice. Formulations containing buspirone have been used in the treatment of generalized anxiety disorder.Formal Name: 8-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl-1,1,2,2,3,3,4,4-d8]-8-azaspiro[4.5]decane-7,9-dione, monohydrochloride. CAS Number: 1216761-39-5. Synonyms: MJ9022-1-d8. Molecular Formula: C21H23D8N5O2 . HCl. Formula Weight: 430.0. Purity: >99% deuterated forms (d1-d8). Formulation: (Request formulation change), A solid. Solubility: Methanol: Soluble. SMILES: O=C1CC2(CCCC2)CC(N1C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])N(CC3)CCN3C4=NC=CC=N4)=O.Cl. InChi Code: InChI=1S/C21H31N5O2.ClH/c27-18-16-21(6-1-2-7-21)17-19(28)26(18)11-4-3-10-24-12-14-25(15-13-24)20-22-8-5-9-23-20,/h5,8-9H,1-4,6-7,10-17H2,1H/i3D2,4D2,10D2,11D2,. InChi Key: RICLFGYGYQXUFH-WPEKBPPBSA-N.