Atazanavir-d6

Atazanavir-d6
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay26456-1 1 mg -

6 - 10 business days*

324.00€
 
Atazanavir-d6 is intended for use as an internal standard for the quantification of atazanavir... more
Product information "Atazanavir-d6"
Atazanavir-d6 is intended for use as an internal standard for the quantification of atazanavir (Cay-11733) by GC- or LC-MS. Atazanavir is an azapeptide inhibitor of HIV-1 protease (Ki = 2.66 nM). It has antiviral activity against a variety of HIV-1 strains in several cell types with EC50 values ranging from 2.62 to 5.28 nM. Atazanavir exhibits a minor synergistic effect when used in combination with the reverse transcriptase inhibitor zidovudine (Cay-15492) in HIV-1-infected human peripheral blood mononuclear cells (PBMCs) and an additive effect when used in combination with several additional reverse transcriptase or HIV-1 protease inhibitors. Atazanavir also inhibits UDP-glucuronyltransferase 1A1 (UGT1A1), which is involved in bilirubin clearance. Formulations containing atazanavir have been used in combination therapy for the treatment of HIV-1 infection.Formal Name: (3S,8S,9S,12S)-3,12-bis(1,1-dimethylethyl)-8-hydroxy-4,11-dioxo-9-(phenylmethyl)-6-[[4-(2-pyridinyl)phenyl]methyl]-2,5,6,10,13-pentaazatetradecanedioic acid, 1,14-di(methyl-d3) ester. CAS Number: 1092540-50-5. Molecular Formula: C38H46D6N6O7. Formula Weight: 710.9. Purity: >99% deuterated forms (d1-d6). Formulation: (Request formulation change), A solid. Solubility: Ethanol: Slightly Soluble, Methanol: Slightly Soluble. SMILES: O=C(N[C@@H](C(C)(C)C)C(N[C@@H](CC1=CC=CC=C1)[C@@H](O)CN(CC2=CC=C(C3=NC=CC=C3)C=C2)NC([C@@H](NC(OC([2H])([2H])[2H])=O)C(C)(C)C)=O)=O)OC([2H])([2H])[2H]. InChi Code: InChI=1S/C38H52N6O7/c1-37(2,3)31(41-35(48)50-7)33(46)40-29(22-25-14-10-9-11-15-25)30(45)24-44(43-34(47)32(38(4,5)6)42-36(49)51-8)23-26-17-19-27(20-18-26)28-16-12-13-21-39-28/h9-21,29-32,45H,22-24H2,1-8H3,(H,40,46)(H,41,48)(H,42,49)(H,43,47)/t29-,30-,31+,32+/m0/s1/i7D3,8D3. InChi Key: AXRYRYVKAWYZBR-ORLNJQPYSA-N. Origin: Synthetic.
Keywords: (3S,8S,9S,12S)-3,12-bis(1,1-dimethylethyl)-8-hydroxy-4,11-dioxo-9-(phenylmethyl)-6-[[4-(2-pyridinyl)phenyl]methyl]-2,5,6,10,13-pentaazatetradecanedioic acid, 1,14-di(methyl-d3) ester
Supplier: Cayman Chemical
Supplier-Nr: 26456

Properties

Application: GC-MS, LC-MS, Internal standard, HIV-1 protease inhibitor
Conjugate: No
MW: 710.9 D
Formula: C38H46D6N6O7
Purity: >99% deuterated forms (d1-d6)
Format: Solid

Database Information

CAS : 1092540-50-5| Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Warning
GHS Hazard Pictograms:
H Phrases: H302, H315, H319, H335
P Phrases: P261, P264, P270, P271, P280, P301+310, P302+352, P304+340, P305+351+338, P312, P321, P330, P332+313, P337+313, P362+364, P403+233, P405, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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