URB597

URB597 is a potent and selective inhibitor of fatty acid amide hydrolase (FAAH), the enzyme that hydrolyzes anandamide (AEA, Cay-90050) and other simple esters and amides with long unsaturated acyl chains (IC50 = 4.6 nM and 0.5 nM in brain membranes and intact neurons, respectively). URB597 exhibits both antinociceptive and anxiolytic effects in vivo without evoking other symptoms associated with cannabinoid-like compounds. This antinociceptive effect is similar to those observed in FAAH(-/-) mice.Formal Name: (3'-(aminocarbonyl)[1,1'-biphenyl]-3-yl)-cyclohexylcarbamate. CAS Number: 546141-08-6. Molecular Formula: C20H22N2O3. Formula Weight: 338.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMF:PBS(pH7.2) (1:1): 500 µg/ml, DMSO: 10 mg/ml, DMSO:PBS (pH 7.2) (1:2): 500 µg/ml, Ethanol: 1 mg/ml. SMILES: O=C(NC1CCCCC1)Oc1cccc(c1)c1cccc(c1)C(=O)N. InChi Code: InChI=1S/C20H22N2O3/c21-19(23)16-8-4-6-14(12-16)15-7-5-11-18(13-15)25-20(24)22-17-9-2-1-3-10-17/h4-8,11-13,17H,1-3,9-10H2,(H2,21,23)(H,22,24). InChi Key: ROFVXGGUISEHAM-UHFFFAOYSA-N.