STX-64

STX-64 is a steroid sulfatase inhibitor (IC50 = 0.008 µM in placental microsomes). It also inhibits carbonic anhydrase II (CAII, IC50 = 0.025 µM). STX-64 inhibits LPS-induced production of nitric oxide (NO) and prostaglandin E2 (PGE2, Cay-14010) in RAW 264.7 macrophages (IC50s = 85.76 and 0.081 µM, respectively). It reduces rat liver steroid sulfatase activity when administered at a dose of 1 mg/kg. STX-64 (2 mg/kg) inhibits estrone sulfate-induced uterine growth and reduces the growth of N-nitroso-N-methylurea-induced, estrone sulfate-maintained mammary tumors in ovariectomized rats.Formal Name: sulfamic acid, 6,7,8,9,10,11-hexahydro-6-oxobenzo[b]cyclohepta[d]pyran-3-yl ester. CAS Number: 288628-05-7. Synonyms: BN83495, 667 Coumate, Irosustat. Molecular Formula: C14H15NO5S. Formula Weight: 309.3. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMF: 30 mg/ml, DMSO: 20 mg/ml. SMILES: O=C1C2=C(CCCCC2)C3=CC=C(OS(N)(=O)=O)C=C3O1. InChi Code: InChI=1S/C14H15NO5S/c15-21(17,18)20-9-6-7-11-10-4-2-1-3-5-12(10)14(16)19-13(11)8-9/h6-8H,1-5H2,(H2,15,17,18). InChi Key: DSLPMJSGSBLWRE-UHFFFAOYSA-N.