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SRT 3025 is an activator of sirtuin 1 (SIRT1). It increases SIRT1 levels in, and inhibits RANKL-induced osteoclastogenesis of, mouse bone marrow-derived macrophages (BMDMs) when used at a concentration of 2 µM. SRT 3025 inhibits the proliferation of SU.86.86 pancreatic adenocarcinoma cells (IC50 = 0.98 µM). It decreases plasma levels of LDL, VLDL, and total cholesterol in ApoE-/- mice fed a high-cholesterol diet when administered at a dose of 3.18 g/kg.Formal Name: 5-(3-methoxypropyl)-2-phenyl-N-[2-[6-(1-pyrrolidinylmethyl)thiazolo[5,4-b]pyridin-2-yl]phenyl]-4-thiazolecarboxamide, monohydrochloride. CAS Number: 2070015-26-6. Molecular Formula: C31H31N5O2S2 . HCl. Formula Weight: 606.2. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Chloroform: 30 mg/ml, DMF: slightly soluble, DMSO: slightly soluble, Ethanol: slightly soluble. lambdamax: 231, 281, 353 nm. SMILES: O=C(C1=C(CCCOC)SC(C2=CC=CC=C2)=N1)NC3=C(C4=NC5=CC(CN6CCCC6)=CN=C5S4)C=CC=C3.Cl. InChi Code: InChI=1S/C31H31N5O2S2.ClH/c1-38-17-9-14-26-27(35-29(39-26)22-10-3-2-4-11-22)28(37)33-24-13-6-5-12-23(24)30-34-25-18-21(19-32-31(25)40-30)20-36-15-7-8-16-36,/h2-6,10-13,18-19H,7-9,14-17,20H2,1H3,(H,33,37),1H. InChi Key: LGRBDTOIPNDWMN-UHFFFAOYSA-N.
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