(S)-Ketorolac

(S)-Ketorolac is a non-selective COX inhibitor and non-steroidal anti-inflammatory drug (NSAID, IC50s = 0.1 and 2.7 µM for COX-1 and COX-2, respectively). (S)-Ketorolac is approximately twice as potent as the racemic mixture (Cay-9001148) and 60 times more potent than (R)-ketorolac in a rat pain assay. (S)-Ketorolac is cleared from rat kidney and liver more quickly than (R)-ketorolac. Formulations containing ketorolac have been used to manage postoperative pain as well as an ophthalmic solution to treat ocular pain and inflammation.Formal Name: (1S)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. CAS Number: 66635-92-5. Synonyms: (-)-Ketorolac. Molecular Formula: C15H13NO3. Formula Weight: 255.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: Chloroform: Slightly, Ethanol: >1mg/ml, Methanol: Slightly. lambdamax: 245, 312 nm. SMILES: O=C(C1=CC=C2N1CC[C@@H]2C(O)=O)C3=CC=CC=C3. InChi Code: InChI=1S/C15H13NO3/c17-14(10-4-2-1-3-5-10)13-7-6-12-11(15(18)19)8-9-16(12)13/h1-7,11H,8-9H2,(H,18,19)/t11-/m0/s1. InChi Key: OZWKMVRBQXNZKK-NSHDSACASA-N.