243 products were found matching "K00509"!

The COX-1 (human) Inhibitor Screening Assay directly measures PGF2alpha by stannous chloride reduction of COX-derived PGH2 produced in the COX reaction. The prostanoid product is quantified via ELISA using an antiserum specific to PGF2alpha. This assay includes recombinant human COX-1 and is an excellent tool for...

The COX (human) Inhibitor Screening Assay directly measures PGF2alpha by stannous chloride reduction of COX-derived PGH2 produced in the COX reaction. The prostanoid product is quantified via ELISA using an antiserum specific to PGF2a. This assay includes recombinant human COX-1 and COX-2 and is an excellent tool...

SC-560 is a member of the diaryl heterocycle class of cyclooxygenase (COX) inhibitors which includes celecoxib (Celebrex(TM)) and rofecoxib (Vioxx(TM)). However, unlike these selective COX-2 inhibitors, SC-560 is a selective inhibitor of COX-1. Using human recombinant enzymes, the IC50 value for SC-560 with respect...

Cyclooxygenase 1 (COX-1) is a bifunctional enzyme that exhibits both COX and peroxidase activities. It is composed of an N-terminal signal peptide, an EGF-like domain, a membrane binding domain, a catalytic domain, and a C-terminal tail. COX-1 is constitutively expressed in the gastrointestinal tract, kidney,...

Diclofenac is a non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor (IC50s = 0.9-2.7 and 1.5-20 µM, for human COX-1 and COX-2, respectively). It is also an active metabolite of diclofenac methyl ester (Cay-22218) and diclofenac amide (Cay-21969). Diclofenac inhibits release of arachidonic acid (Cay-90010,...

The COX Colorimetric Inhibitor Screening Assay measures the peroxidase component of cyclooxygenases. The peroxidase activity is assayed colorimetrically by monitoring the appearance of oxidized N,N,N',N'-tetramethyl-p-phenylenediamine (TMPD) at 590 nm. Inhibition of COX activity, measured by TMPD oxidation, by a...

trans-Resveratrol is a polyphenol that has been found in grapes and has diverse biological activities. It inhibits the cyclooxygenase and hydroperoxidase activities of COX-1 (EC50s = 15 and 3.7 µM, respectively) but not COX-2 (EC50s = >100 µM and 85 µM, respectively). trans-Resveratrol (200 µM) also activates...

A non-selective COX inhibitor (IC50s = 0.04 and 0.51 µM for COX-1 and COX-2, respectively), reduces carrageenan-induced hind paw edema and yeast-induced fever in rats from 0.3-4.8 mg/kg, reduces plasma fibrinogen levels and arthritic score in a rat model of adjuvant-induced arthritis, reduces tumor weight and...

An NSAID and inhibitor of the peroxidase activity of COX (IC50 = ~100 µM in the presence of hydrogen peroxide), inhibits prostaglandin I synthase (IC50 = ~25 µM in the presence of hydrogen peroxide), reduces increases in type II collagen levels in the inflamed joints of an equine model of LPS-induced acute synovitis...

A time-dependent, non-specific COX inhibitor with IC50 values of 1.5 and 9.7 µM for human recombinant COX-1 and COX-2, respectively. Formulation: A crystalline solid. InChI: InChI=1S/C14H11Cl2NO2.Na/c1-8-6-7-10(15)13(12(8)16)17-11-5-3-2-4-9(11)14(18)19,/h2-7,17H,1H3,(H,18,19),/q,+1/p-1. InChIKey:...

An NSAID and a COX inhibitor (IC50s = 0.9-2.7 and 1.5-20 µM, for human COX-1 and COX-2, respectively), inhibits A23187-induced release of arachidonic acid in isolated rat peritoneal neutrophils and macrophages (IC50s = 60 and 10 µM, respectively), inhibits carrageenan-induced paw edema in rats. Formulation: A...

An NSAID and COX inhibitor, inhibits COX-1 and COX-2 in COS-1 cells expressing the human enzymes (IC50s = 4.8 and 28.4 µM, respectively), inhibits TXB2 and PGE2 production ex vivo in isolated rat blood (IC50s = 5 and 13 µM, respectively). Formulation: A crystalline solid. InChI:...