257 products were found matching "K00509"!

Proquazone is a non-steroidal anti-inflammatory drug (NSAID). It reduces carrageenan-induced edema in rats (ED50 = 5 mg/kg, p.o.) and bradykinin-induced bronchoconstriction in guinea pigs (ED50 = 0.01 mg/kg, i.v.). It also inhibits yeast-induced pyresis in rats. Formulations containing proquazone have been used in...

The COX-1 (human) Inhibitor Screening Assay directly measures PGF2alpha by stannous chloride reduction of COX-derived PGH2 produced in the COX reaction. The prostanoid product is quantified via ELISA using an antiserum specific to PGF2alpha. This assay includes recombinant human COX-1 and is an excellent tool for...

The COX (human) Inhibitor Screening Assay directly measures PGF2alpha by stannous chloride reduction of COX-derived PGH2 produced in the COX reaction. The prostanoid product is quantified via ELISA using an antiserum specific to PGF2a. This assay includes recombinant human COX-1 and COX-2 and is an excellent tool...

SC-560 is a member of the diaryl heterocycle class of cyclooxygenase (COX) inhibitors which includes celecoxib (Celebrex(TM)) and rofecoxib (Vioxx(TM)). However, unlike these selective COX-2 inhibitors, SC-560 is a selective inhibitor of COX-1. Using human recombinant enzymes, the IC50 value for SC-560 with respect...

Cyclooxygenase 1 (COX-1) is a bifunctional enzyme that exhibits both COX and peroxidase activities. It is composed of an N-terminal signal peptide, an EGF-like domain, a membrane binding domain, a catalytic domain, and a C-terminal tail. COX-1 is constitutively expressed in the gastrointestinal tract, kidney,...

The COX Colorimetric Inhibitor Screening Assay measures the peroxidase component of cyclooxygenases. The peroxidase activity is assayed colorimetrically by monitoring the appearance of oxidized N,N,N',N'-tetramethyl-p-phenylenediamine (TMPD) at 590 nm. Inhibition of COX activity, measured by TMPD oxidation, by a...

trans-Resveratrol is a polyphenol that has been found in grapes and has diverse biological activities. It inhibits the cyclooxygenase and hydroperoxidase activities of COX-1 (EC50s = 15 and 3.7 µM, respectively) but not COX-2 (EC50s = >100 µM and 85 µM, respectively). trans-Resveratrol (200 µM) also activates...

Diclofenac is a non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor (IC50s = 0.9-2.7 and 1.5-20 µM, for human COX-1 and COX-2, respectively). It is also an active metabolite of diclofenac methyl ester (Cay-22218) and diclofenac amide (Cay-21969). Diclofenac inhibits release of arachidonic acid (Cay-90010,...

Guaiacol is a phenolic natural product first isolated from Guaiac resin and the oxidation of lignin. Guaiacol is readily oxidized by the heme iron of peroxidases including the peroxidase of cyclooxygenase (COX) enzymes. It therefore serves as a reducing co-substrate for COX reactions. The color yield per peroxide at...

Cyclooxygenase 1 (COX-1) is a bifunctional enzyme that exhibits both COX and peroxidase activities. It is composed of an N-terminal signal peptide, an EGF-like domain, a membrane binding domain, a catalytic domain, and a C-terminal tail. COX-1 is constitutively expressed in the gastrointestinal tract, kidney,...

Indomethacin is a non-selective COX inhibitor (IC50s = 1.67 and 24.6 µM for human COX-1 and COX-2, respectively). It reduces filter paper-disc induced growth of granulation tissue, a marker of inflammation, in chick chorioallantoic membranes. Indomethacin reduces ocular inflammation induced by bovine serum in...

Cyclooxygenase 1 (COX-1) is a bifunctional enzyme that exhibits both COX and peroxidase activities. It is composed of an N-terminal signal peptide, an EGF-like domain, a membrane binding domain, a catalytic domain, and a C-terminal tail. COX-1 is constitutively expressed in the gastrointestinal tract, kidney,...