PIK-93

PIK-93 is an inhibitor of phosphatidylinositol 4-kinase IIIbeta (PI4KIIIbeta, IC50 = 19 nM). It is selective for PI4KIIIbeta over PI4KIIIalpha and PI4KIIalpha (IC50s = 1,100 and >100,000 nM, respectively). However, it also inhibits the PI3K catalytic subunits (IC50s = 39, 590, 120, and 16 nM for p110alpha, p110beta, p110delta, and p110gamma, respectively). PIK-93 reduces enteroviral RNA replication when used at a concentration of 125 nM in HeLa cells. It also inhibits the transport of ceramide from the endoplasmic reticulum to the Golgi apparatus.Formal Name: N-[5-[4-chloro-3-[[(2-hydroxyethyl)amino]sulfonyl]phenyl]-4-methyl-2-thiazolyl]-acetamide. CAS Number: 593960-11-3. Molecular Formula: C14H16ClN3O4S2. Formula Weight: 389.9. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5 mg/ml, DMSO: 5 mg/ml, Ethanol: 0.25 mg/ml. lambdamax: 203, 306 nm. SMILES: ClC1=C(S(NCCO)(=O)=O)C=C(C2=C(C)N=C(NC(C)=O)S2)C=C1. InChi Code: InChI=1S/C14H16ClN3O4S2/c1-8-13(23-14(17-8)18-9(2)20)10-3-4-11(15)12(7-10)24(21,22)16-5-6-19/h3-4,7,16,19H,5-6H2,1-2H3,(H,17,18,20). InChi Key: JFVNFXCESCXMBC-UHFFFAOYSA-N.