26 products were found matching "K19801"!

0.5mg/ml if reconstituted with 0.2ml sterile DI water. Pi4kb (Phosphatidylinositol 4-kinase beta) is an enzyme involved in the phosphoinositide signaling pathway, playing a key role in the synthesis of phosphatidylinositol 4-phosphate (PI4P), a lipid molecule that serves as a precursor for other important...

0.5mg/ml if reconstituted with 0.2ml sterile DI water. Phosphatidylinositol 4-kinase beta is an enzyme that in humans is encoded by the PI4KB gene. Inositol phospholipids have an important role in intracellular signaling in response to hormones, growth factors and neurotransmitters. Phosphatidylinositol 4-kinase...

UCB 9608 is an inhibitor of PI4KIIIbeta (IC50 = 11 nM). It is selective for PI4KIIIbeta over 8 other phosphatidylinositol kinases at 10 µM. UCB 9608 inhibits the mixed lymphocyte reaction in isolated human peripheral blood mononuclear cells (PBMCs, IC50 = 37 nM). It increases heart allograft survival in mice when...

PIK-93 is an inhibitor of phosphatidylinositol 4-kinase IIIbeta (PI4KIIIbeta, IC50 = 19 nM). It is selective for PI4KIIIbeta over PI4KIIIalpha and PI4KIIalpha (IC50s = 1,100 and >100,000 nM, respectively). However, it also inhibits the PI3K catalytic subunits (IC50s = 39, 590, 120, and 16 nM for p110alpha, p110beta,...

Protein function: Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol- 1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation. Involved in Golgi-to-plasma membrane trafficking....

Protein function: Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol- 1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation. Involved in Golgi-to-plasma membrane trafficking....

Anti-PI4K beta was affinity purified from monospecific antiserum by immunoaffinity chromatography. A BLAST analysis was used to suggest cross-reactivity with bat, rat, primate, mouse, and human based on 100% sequence homology. Cross-reactivity with PI4K beta from other sources has not been determined....

Protein function: Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol- 1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation. Involved in Golgi-to-plasma membrane trafficking....

Protein function: Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol- 1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation. Involved in Golgi-to-plasma membrane trafficking....

Description: PI4KIII beta inhibitor 3 is a novel, highly effective inhibitor of PI4KIIIbeta with an IC50 of 5.7 nM. Target: PI3K. Smiles: Cc1ccc(NC(=O)N2CCN(CC2)c2nc(N)nc3sc(nc23)-c2cccnc2)cc1. References: Jean Herman, et al. Autoimmune and inflammatory disorder therapy. From PCT Int. Appl. (2013), WO 2013034738 A1

Description: PIK-93, the first potent synthetic PI4K inhibitor, exhibits an IC50 of 19 nM and also inhibits PI3Kalpha with an IC50 of 39 nM. Target: PI3K, mTOR, ATM/ATR, PI4K, DNA-PK, HSV, Carbonic Anhydrase, Virus Protease. Smiles: CC(=O)Nc1nc(C)c(s1)-c1ccc(Cl)c(c1)S(=O)(=O)NCCO. References: Knight ZA, Cell,...

PI4KIIIbeta inhibitor 3 is an inhibitor of PI4KIIIbeta (IC50 = 19 nM). It is approximately 100-fold selective for PI4KIIIbeta over PI4KIIalpha, PI4KIIbeta, and PI4KIIIalpha, PI3Kalpha, PI3Kbeta, PI3Kgamma, and PI3Kdelta, and PI3KC3, as well as 100-500-fold selective over PI3KC2alpha, PI3KC2beta, and...