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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay10010660-500 | 500 µg | - |
6 - 10 business days* |
279.00€
|
|||
Cay10010660-1 | 1 mg | - |
6 - 10 business days* |
524.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Mifepristone-d3 is intended for use as an internal standard for the quantification of... more
Product information "Mifepristone-d3"
Mifepristone-d3 is intended for use as an internal standard for the quantification of mifepristone (Cay-10006317) by GC- or LC-MS. Mifepristone is an antagonist of glucocorticoid, progesterone, and androgen receptors (Kis = 0.1, 0.64, and 0.65 nM, respectively). It is selective for these receptors over the mineralocorticoid receptor (MR), estrogen receptor alpha (ERalpha), and ERbeta (Kis = 640, >200, and >750 nM, respectively). In cell-based assays, mifepristone inhibits alkaline phosphatase activity stimulated by the progesterone receptor agonist R5020 as well as reporter transcription stimulated by either dexamethasone (Cay-11015) or R5020 (IC50s = 7, 5.9, and 1.3 nM, respectively). It also inhibits synthetic androgen R1881-stimulated reporter transcription in a concentration-dependent manner. Mifepristone (10 µM) inhibits growth of 4-OHT-resistant MCF-7 breast cancer cells in vitro. It also inhibits tumor growth in an SKOV3 ovarian cancer nude mouse xenograft model when administered at doses of 0.5 or 1 mg per day. Formulations containing mifepristone have been used for the induction of medical abortions.Formal Name: 11beta-[4-(dimethylamino-d3)phenyl]-17beta-hydroxy-17-(1-propynyl)-estra-4,9-dien-3-one. Molecular Formula: C29H32D3NO2. Formula Weight: 432.6. Purity: >99% deuterated forms (d1-d3). Formulation: (Request formulation change), A crystalline solid. Solubility: Chloroform: Soluble, Methanol: Soluble. SMILES: O=C1CCC(C(CC2)=C1)=C([C@]2([H])[C@@](CC[C@]3(C#CC)O)([H])[C@]3(C)C4)[C@H]4C5=CC=C(N(C([2H])([2H])[2H])C)C=C5. InChi Code: InChI=1S/C29H35NO2/c1-5-15-29(32)16-14-26-24-12-8-20-17-22(31)11-13-23(20)27(24)25(18-28(26,29)2)19-6-9-21(10-7-19)30(3)4/h6-7,9-10,17,24-26,32H,8,11-14,16,18H2,1-4H3/t24-,25+,26-,28-,29-/m0/s1/i3D3. InChi Key: VKHAHZOOUSRJNA-PBWRPEOTSA-N.
Keywords: | 11beta-[4-(dimethylamino-d3)phenyl]-17beta-hydroxy-17-(1-propynyl)-estra-4,9-dien-3-one |
Supplier: | Cayman Chemical |
Supplier-Nr: | 10010660 |
Properties
Application: | Progesterone inhibitor |
MW: | 432.6 D |
Formula: | C29H32D3NO2 |
Purity: | >99% deuterated forms (d1-d3) |
Format: | Crystalline Solid |
Database Information
KEGG ID : | K08556 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: -20°C) |
Signal Word: | Danger |
GHS Hazard Pictograms: |
|
H Phrases: | H302, H312, H332, H360 |
P Phrases: | P201, P202, P261, P264, P270, P271, P280, P301+310, P302+352, P304+340, P308+313, P312, P321, P330, P361+364, P405, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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