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Lornoxicam is a COX inhibitor and non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory and analgesic properties. It inhibits production of thromboxane B2 (TXB2, Cay-19030) from arachidonic acid (Cay-90010, Cay-90010.1, Cay-10006607) in HEL human erythroleukemic cells (IC50 = 3 nM), which endogenously express COX-1, as well as inhibits LPS-induced formation of prostaglandin F1alpha (PGF1alpha, Cay-15010) from arachidonic acid in Mono-Mac-6 cells (IC50 = 8 nM), which endogenously express COX-2. Lornoxicam reduces LPS-induced production of nitric oxide and IL-6 in cell-based assays with IC50 values of 65 and 54 µM, respectively. It reduces carrageenan-induced paw edema in rats when administered intravenously at doses ranging from 0.1 to 9 mg/kg. Formulations containing lornoxicam have been used in the management of postoperative pain.Formal Name: 6-chloro-4-hydroxy-2-methyl-N-2-pyridinyl-2H-thieno[2,3-e]-1,2-thiazine-3-carboxamide-1,1-dioxide. CAS Number: 70374-39-9. Synonyms: Chlortenoxicam, Ro 13-9297. Molecular Formula: C13H10ClN3O4S2. Formula Weight: 371.8. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: < 1mg/mL, DMSO: 2 mg/mL, Ethanol: < 1mg/mL, Water: < 1 mg/mL. lambdamax: 270, 381 nm. SMILES: ClC(S1)=CC2=C1C(O)=C(C(N([H])C3=CC=CC=N3)=O)N(C)S2(=O)=O. InChi Code: InChI=1S/C13H10ClN3O4S2/c1-17-10(13(19)16-9-4-2-3-5-15-9)11(18)12-7(23(17,20)21)6-8(14)22-12/h2-6,18H,1H3,(H,15,16,19). InChi Key: WLHQHAUOOXYABV-UHFFFAOYSA-N.
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