Indomethacin

Indomethacin is a non-selective COX inhibitor (IC50s = 1.67 and 24.6 µM for human COX-1 and COX-2, respectively). It reduces filter paper-disc induced growth of granulation tissue, a marker of inflammation, in chick chorioallantoic membranes. Indomethacin reduces ocular inflammation induced by bovine serum in rabbits. It also reduces paw edema in a rat model of carrageenan-induced inflammation.Formal Name: 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid. CAS Number: 53-86-1. Molecular Formula: C19H16ClNO4. Formula Weight: 357.8. Purity: >99%. Formulation: (Request formulation change), A crystalline solid. Solubility: 0.1 M Na2CO3: 0.1 mg/ml (warming is required, DMF: >20.2 mg/ml, DMSO: >17.8 mg/ml, ETOH: >6.73 mg/ml, PBS (pH 7.2): <50 µg/ml. SMILES: CC1=C(CC(O)=O)C(C=C(OC)C=C2)=C2N1C(C3=CC=C(Cl)C=C3)=O. InChi Code: InChI=1S/C19H16ClNO4/c1-11-15(10-18(22)23)16-9-14(25-2)7-8-17(16)21(11)19(24)12-3-5-13(20)6-4-12/h3-9H,10H2,1-2H3,(H,22,23). InChi Key: CGIGDMFJXJATDK-UHFFFAOYSA-N.