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IMMA is a cannabinoid (CB) receptor 2 inverse agonist (Ki = 435 nM for recombinant human CB2). It is selective for CB2 over CB1 receptors (Ki = >20 µM). IMMA (0.001-1 µM) reduces basal production of inositol phosphate and increases forskolin-induced accumulation of cAMP in HEK293 cells expressing human CB2 receptors. It inhibits LPS-induced nitric oxide (NO) and prostaglandin E2 (PGE2: Cay-14010) production in J774 macrophages in a concentration-dependent manner.Formal Name: 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-1-(4-morpholinyl)-ethanone. CAS Number: 2854-32-2. Synonyms: BML-190, Indomethacin Morpholinylamide, LM-4131. Molecular Formula: C23H23ClN2O4. Formula Weight: 426.9. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMSO: 12.75 mg/ml, Ethanol: 1.25 mg/ml, PBS acidic: 50 µg/ml, PBS basic: 50 µg/ml, PBS pH 7.2: 50 µg/ml. SMILES: CC1=C(C(C=C(OC)C=C2)=C2N1C(C3=CC=C(Cl)C=C3)=O)CC(N4CCOCC4)=O. InChi Code: InChI=1S/C23H23ClN2O4/c1-15-19(14-22(27)25-9-11-30-12-10-25)20-13-18(29-2)7-8-21(20)26(15)23(28)16-3-5-17(24)6-4-16/h3-8,13H,9-12,14H2,1-2H3. InChi Key: BJSDNVVWJYDOLK-UHFFFAOYSA-N.
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