106 products were found matching "K04278"!

Emindole SB is an indoloditerpene that has been found in D. cejpii and has diverse biological activities. It is a cannabinoid 1 (CB1) and CB2 receptor antagonist (Kis = 7. and 2. µM, respectively). Emindole SB inhibits protein tyrosine phosphatase 1B (PTP1B) and T cell protein tyrosine phosphatase (TCPTP. IC50s = 1....

The Cannabinoid receptor 2 (CNR2) is a Gi/o-coupled GPCR expressed in spleen, tonsils, bone marrow and peripheral blood leukocytes. There is one report that cannabinoid-induced inhibition of helper T cell activation is lost in macrophages obtained from CNR2 knockout mice. CNR2 is a potential therapeutic target in...

Cannabidiol (Cay-90080) is an analytical reference material categorized as a phytocannabinoid. Unlike Delta9-THC (Cay-ISO60157, Cay-12068), cannabidiol is non-psychoactive. This product is intended for research and forensic applications.Formal Name:...

AM630 binds selectively to cannabinoid 2 (CB2) over CB1 receptors with Ki values of 31.2 and 5,152 nM, respectively. AM630 acts as an inverse agonist at CB2 receptors, attenuating the antinociceptive effects of a number of cannabinoids, and as a weak partial agonist at CB1 receptors. It decreases proliferation and...

The CB2 receptor is localized predominantly in peripheral tissues, including the spleen and hemopoietic cells. The CB1 and CB2 receptors are G-protein coupled receptors that bind the active component of cannabis, Delta9-tetrahydrocannabinol, as well as anandamide which is an endogenous CB receptor ligand. This...

SR 144528 is a cannabinoid 2 (CB2) receptor antagonist (Ki = 0.6 nM). It is selective for CB2 over CB1 receptors in CHO cells expressing the human receptors (Ki = 437 nM). SR 144528 reverses CP 55,940-induced inhibition of forskolin-induced adenylyl cyclase activity in CHO cells expressing human CB2 receptors (EC50...

CB-65 is a cannabinoid 2 (CB2) receptor inverse agonist. It selectively binds to CB2 over CB1 receptors (Kis = 3. nM and >1,000 nM, respectively) and increases forskolin-induced cAMP production in CHO cells expressing the human CB2 receptor (EC50 = 1. nM). CB-65 (0. 2. and 20 nM) inhibits HepG2 hepatocellular...

Dihomo-gamma-linolenoyl ethanolamide is an endocannabinoid containing dihomo-gamma-linoleate in place of the arachidonate moiety of AEA. Dihomo-gamma-linolenoyl ethanolamide binds to recombinant human CB1 and CB2 receptors with Ki values of 857 and 598 nM, respectively. Its specific role and relative importance as a...

Tetrahydromagnolol is an agonist of cannabinoid (CB) receptors, an antagonist of GPR55 (KB = 13.3 µM in a beta-arrestin translocation assay), and a major metabolite of magnolol (Cay-14233). Tetrahydromagnolol binds to the CB1 and CB2 receptors (Kis = 2.26 and 0.416 µM, respectively, for the human receptor) and...

beta-Caryophyllene (Cay-21572) is a sesquiterpene that has been found in plants, including C. sativa, C. indica, and hemp, and has diverse biological activities, including lipid metabolic, antioxidant, anti-neuroinflammatory, anti-proliferative, and antinociceptive properties. It is an agonist of the cannabinoid...

Magnolol is a bioactive compound isolated from the bark of M. officinalis that has been used in Asian traditional medicine for the treatment of anxiety, sleep disorders, and allergic diseases. Magnolol can activate cannabinoid (CB) receptors, behaving as a partial agonist with selectivity for the peripheral CB2...

(-)-CP 55,940 (Cay-90084) is an analytical reference standard categorized as a synthetic cannabinoid. This product is intended for research and forensic applications.Formal Name: 5-(1,1-dimethylheptyl)-2-[(1R,2R,5R)-5-hydroxy-2-(3-hydroxypropyl)cyclohexyl]-phenol. CAS Number: 83002-04-4. Molecular Formula: C24H40O3....