This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the comfort when using this website, are used for direct advertising or to facilitate interaction with other websites and social networks, are only set with your consent.
Configuration
Technically required
These cookies are necessary for the basic functions of the shop.
"Allow all cookies" cookie
"Decline all cookies" cookie
CSRF token
Cookie preferences
Currency change
Customer-specific caching
FACT-Finder tracking
Individual prices
Selected shop
Session
Comfort functions
These cookies are used to make the shopping experience even more appealing, for example for the recognition of the visitor.
Note
Show the facebook fanpage in the right blod sidebar
Statistics & Tracking
Affiliate program
Conversion and usertracking via Google Tag Manager
Product information "Cinnamyl-3,4-dihydroxy-alpha-Cyanocinnamate"
Cinnamyl-3,4-dihydroxy-alpha-cyanocinnamate (CDC) is an inhibitor of 5-lipoxygenase (5-LO, IC50 = 15 nM). It is selective for 5-LO over 12-LO and 15-LO (IC50s = 500 and 300 nM, respectively). CDC inhibits 5-LO product formation induced by the calcium ionophore A23187 (Cay-11016) in isolated human polymorphonuclear leukocytes (PMNs), monocytes, and whole blood (IC50s = 0.5, 0.45, and 1.5 µM, respectively). In vivo, CDC (3.5 mg/kg) increases survival in a mouse model of lethal shock induced by platelet-activating factor (PAF). It also reduces pleural levels of leukotriene B4 (LTB4, Cay-20110) in a rat model of carrageenan-induced pleurisy.Formal Name: (2E)-2-cyano-3-(3,4-dihydroxyphenyl)-2-propenoic acid, 3-phenyl-2-propen-1-yl ester. CAS Number: 132465-11-3. Synonyms: CDC. Molecular Formula: C19H15NO4. Formula Weight: 321.3. Purity: >97%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, DMSO:PBS (pH 7.2) (1:10): 0.1 mg/ml, Ethanol: 0.25 mg/ml. lambdamax: 251, 376 nm. SMILES: O=C(/C(C#N)=C/C1=CC=C(O)C(O)=C1)OC/C=C/C2=CC=CC=C2. InChi Code: InChI=1S/C19H15NO4/c20-13-16(11-15-8-9-17(21)18(22)12-15)19(23)24-10-4-7-14-5-2-1-3-6-14/h1-9,11-12,21-22H,10H2/b7-4+,16-11+. InChi Key: XGHYFEJMJXGPGN-UYHGDYIZSA-N.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
More information