136 products were found matching "K00461"!

Description: ALOX5 Protein, Human, Recombinant (His) is expressed in E. coli. The accession number is P09917.

Zileuton is a reversible 5-lipoxygenase (5-LO) inhibitor. It inhibits 5-LO activity in rat basophilic leukemia-1 (RBL-1) cell supernatant with an IC50 value of 0.5 µM. Zileuton inhibits leukotriene B4 (LTB4, Cay-20110) production induced by the calcium ionophore A23187 (Cay-11016) in purified human peripheral blood...

Oleacein is a secoiridoid polyphenol that has been found in O. europea and has diverse biological activities. It inhibits 5-lipoxygenase (5-LO, IC50 = 2 µM for the human enzyme). Oleacein (20 and 50 µM) reduces lipid accumulation and inhibits the transition into foam cells in human monocyte-derived macrophages. It...

Arachidonic acid (Cay-90010) and selected other polyunsaturated fatty acids are stereoselectively oxygenated at carbon 5 by the non-heme iron containing enzyme 5-lipoxygenase (5-LO). The intervention of a second protein, 5-LO-activating protein (FLAP), is required before 5-LO can become catalytically active. MK-886...

5-Lipoxygenase (5-LO) is an enzyme encoded by ALOX5 in humans that is involved in leukotriene biosynthesis. It is composed of an N-terminal regulatory domain and a C-terminal catalytic domain and is primarily expressed in leukocytes. Increases in intracellular calcium levels or cellular stress induce translocation...

15(S)-HETrE is the hydroxy-trienoic acid resulting from 15-lipoxygenation of dihomo-gamma-linolenic acid (DGLA, Cay-90230). It is an inhibitor of 5-LO in human PMNL with an IC50 value of 4.6 µM. In RBL cells, 15(S)-HETrE inhibits 5-LO, but is about 1/20 as potent as 15(S)-HpETE.Formal Name:...

3-acetyl-11-keto-beta-Boswellic acid is a naturally occurring pentacyclic triterpene isolated from the gum resin exudate from the stem of the tree B. serrata (frankincense). It selectively inhibits 5-lipoxygenase (IC50 = 1.5 µM) in an enzyme-directed, nonredox, and noncompetitive manner....

AA-861 is an inhibitor of 5-lipoxygenase (5-LO, IC50 = 0.8 µM). It is greater than 100-fold selective for 5-LO over 12-LO and cyclooxygenase (COX). AA-861 inhibits the production of 5-HETE and leukotriene B4 (LTB4, Cay-20110, Cay-10007240) induced by A23187 (Cay-22030) with IC50 values of 0.03 and 0.08 µM,...

5-Lipoxygenase (5-LO) is an enzyme encoded by ALOX5 in humans that is involved in leukotriene biosynthesis. It is comprised of an N-terminal regulatory domain and a C-terminal catalytic domain and is primarily expressed in leukocytes. Increases in intracellular calcium levels or cellular stress induce translocation...

CJ-13610 is an inhibitor of 5-lipoxygenase (5-LO) that inhibits 5-LO product formation in human polymorphonuclear leukocytes (PMNLs) challenged with A23187 (Cay-11016) in vitro (IC50 = 70 nM). It inhibits recombinant 5-LO in a glutathione peroxidase-dependent manner (IC50 = 300 nM). CJ-13610 also inhibits 5-LO...

Solid. Soluble in DMSO, ethanol, methanol, acetone, ethylacetate or chloroform. Insoluble in water or hexane. Potent inhibitor of human 5-lipoxygenase (5-LO). This enzyme catalyzes two initial steps in the conversion of arachidonic acid into leukotrienes, well known mediators of inflammatory and allergic reactions,...

Off-white solid to pale yellow solid. Soluble in DMSO, dichloromethane, acetone or 100% ethanol. Poorly soluble in water. Anti-inflammatory compound. Potent dual inhibitor of pro-inflammatory transcription factors and inflammatory enzymes, Inhibitor of NFkappaB activation, Potent inhibitor of inducible microsomal...