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MK-886 (sodium salt)
MK-886 (sodium salt)

Item number: Cay10133-5

Arachidonic acid (Cay-90010) and selected other polyunsaturated fatty acids are stereoselectively oxygenated at carbon 5 by the non-heme iron containing enzyme 5-lipoxygenase (5-LO). The intervention of a second protein, 5-LO-activating protein (FLAP), is required before 5-LO can become catalytically active. MK-886...
Keywords: 1-[(4-chlorophenyl)methyl]-3-[(1,1-dimethylethyl)thio]-alpha,alpha-dimethyl-5-(1-methylethyl)-1H-indole-2-propanoic acid,...
Application: Leukotriene biosynthesis inhibitor
CAS 118427-55-7
MW: 494.1 D
From 32.00€ *
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Zileuton
Zileuton

Item number: Cay10006967-10

Zileuton is a reversible 5-lipoxygenase (5-LO) inhibitor. It inhibits 5-LO activity in rat basophilic leukemia-1 (RBL-1) cell supernatant with an IC50 value of 0.5 µM. Zileuton inhibits leukotriene B4 (LTB4, Cay-20110) production induced by the calcium ionophore A23187 (Cay-11016) in purified human peripheral blood...
Keywords: Zyflo(TM), N-(1-benzo[b]thien-2-ylethyl)-N-hydroxy-urea
Application: 5-LO inhibitor
CAS 111406-87-2
MW: 236.3 D
From 20.00€ *
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Anti-5-Lipoxygenase
Anti-5-Lipoxygenase

Item number: Cay160402-500

5-Lipoxygenase (5-LO) catalyzes the formation of 5(S)-HpETE from arachidonic acid as well as its subsequent conversion to leukotriene A4. 5-LO is located in the cytosol of quiescent cells. Upon stimulation of the cell, 5-LO translocates to the nuclear membrane where it is found in association with 5-LO activating...
Keywords: Anti-5-LO, Anti-LOG5, Anti-ALOX5, EC=1.13.11.34, Anti-5-lipoxygenase, Anti-Arachidonate 5-lipoxygenase
Application: WB, ICC, IHC
Reactivity: Human, Rat, Murine, Hamster, Swine
324.00€ *
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3-acetyl-11-keto-beta-Boswellic Acid
3-acetyl-11-keto-beta-Boswellic Acid

Item number: Cay11672-1

3-acetyl-11-keto-beta-Boswellic acid is a naturally occurring pentacyclic triterpene isolated from the gum resin exudate from the stem of the tree B. serrata (frankincense). It selectively inhibits 5-lipoxygenase (IC50 = 1.5 µM) in an enzyme-directed, nonredox, and noncompetitive manner....
Keywords: 3-O-acetyl-11-keto-beta-Boswellic acid, AKBA, (3alpha,4beta)-3-(acetyloxy)-11-oxo-urs-12-en-23-oic acid
Application: 5-lipoxygenase inhibitor
CAS 67416-61-9
MW: 512.7 D
From 37.00€ *
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15(S)-HETrE
15(S)-HETrE

Item number: Cay36720-25

15(S)-HETrE is the hydroxy-trienoic acid resulting from 15-lipoxygenation of dihomo-gamma-linolenic acid (DGLA, Cay-90230). It is an inhibitor of 5-LO in human PMNL with an IC50 value of 4.6 µM. In RBL cells, 15(S)-HETrE inhibits 5-LO, but is about 1/20 as potent as 15(S)-HpETE.
Keywords: 15S-hydroxy-8Z,11Z,13E-eicosatrienoic acid
Application: 5-LO inhibitor
CAS 92693-02-2
MW: 322.5 D
From 80.00€ *
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Cirsiliol
Cirsiliol

Item number: Cay30874-1

Cirsiliol is a flavonoid that has been found in S. indicum and has diverse biological activities. It inhibits 5-lipoxygenase (5-LO) and 12-LO (IC50s = 0.1 and 1 µM, respectively). Cirsiliol inhibits the release of slow-reacting substance of anaphylaxis (SRS-A) in passively sensitized isolated guinea pig lung (IC50 =...
Keywords: Crisiliol, 2-(3,4-dihydroxyphenyl)-5-hydroxy-6,7-dimethoxy-4H-1-benzopyran-4-one
Application: Bioactive flavonoid, 5-lipoxygenase inhibitor
CAS 34334-69-5
MW: 330.3 D
From 32.00€ *
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Esculetin
Esculetin

Item number: Cay19286-1

Esculetin is a natural plant phenolic that shares features of coumarins and catechols. It inhibits lipoxygenases (LOs), including 5-LO and 12-LO (ID50s = 4 and 2.5 µM, respectively). This action is likely due to its ability to bind iron, as it also inhibits other iron-containing enzymes, including the...
Keywords: 6,7-Dihydroxycoumarin, Aesculetin, Cichorigenin, NSC 26427, 6,7-dihydroxy-2H-1-benzopyran-2-one
Application: Iron chelator, Iron-containing enzyme inhibitor, Apoptosis inducer, Antioxidant
CAS 305-01-1
MW: 178.1 D
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Lipoxygenin
Lipoxygenin

Item number: Cay26310-1

Lipoxygenin is an inhibitor of 5-lipoxygenase (5-LO) with an IC50 value of 5 µM for inhibition of 5-LO product synthesis in isolated human granulocytes stimulated with the cation ionophore A23187 (Cay-22030). It inhibits hedgehog-dependent signaling in Shh-LIGHT2 cells and TGF-beta-, activin A-, bone morphogenic...
Keywords: naphthalen-2-yl(2',4,6-trimethoxy-[3,3'-bipyridin]-5-yl)methanol
Application: 5-LO inhibitor
MW: 402.4 D
From 44.00€ *
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CJ-13610
CJ-13610

Item number: Cay21764-1

CJ-13610 is an inhibitor of 5-lipoxygenase (5-LO) that inhibits 5-LO product formation in human polymorphonuclear leukocytes (PMNLs) challenged with A23187 (Cay-11016) in vitro (IC50 = 70 nM). It inhibits recombinant 5-LO in a glutathione peroxidase-dependent manner (IC50 = 300 nM). CJ-13610 also inhibits 5-LO...
Keywords: tetrahydro-4-[3-[[4-(2-methyl-1H-imidazol-1-yl)phenyl]thio]phenyl]-2H-pyran-4-carboxamide
Application: 5-lipoxygenase inhibitor
CAS 179420-17-8
MW: 393.5 D
From 37.00€ *
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Anti-phospho-5 Lipoxygenase (Ser523)
Anti-phospho-5 Lipoxygenase (Ser523)

Item number: ARG52216.50

Protein function: Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes. [The UniProt Consortium]
Keywords: Anti-phospho-5-LO, Anti-phospho-LOG5, Anti-phospho-ALOX5, EC=1.13.11.34, Anti-phospho-5-lipoxygenase,...
Application: WB
Reactivity: Human, Rat
467.00€ *
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Human 5-LO (Arachidonate 5-Lipoxygenase) CLIA Kit
Human 5-LO (Arachidonate 5-Lipoxygenase) CLIA Kit

Item number: G-HUES00179.96

ELISA Type: CLIA. Sensitivity: 37.5 pg/mL. Range: 62.5--4000 pg/mL. Protein function: Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes. [The UniProt Consortium]
Keywords: 5-LO, LOG5, ALOX5, EC=1.13.11.34, 5-lipoxygenase, Arachidonate 5-lipoxygenase
Application: CLIA
Reactivity: Human
629.00€ *
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Human 5-LO (Arachidonate 5-Lipoxygenase) ELISA Kit
Human 5-LO (Arachidonate 5-Lipoxygenase) ELISA Kit

Item number: G-HUES01476.96

ELISA Type: Sandwich. Sensitivity: 0.094ng/mL. Range: 0.156--10ng/mL. Protein function: Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes. [The UniProt Consortium]
Keywords: 5-LO, LOG5, ALOX5, EC=1.13.11.34, 5-lipoxygenase, Arachidonate 5-lipoxygenase
Application: Sandwich ELISA
Reactivity: Human
566.00€ *
Review
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