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5-Aminosalicylic acid (5-ASA) is a non-steroidal anti-inflammatory drug (NSAID) and an active metabolite of sulfasalazine (Cay-15025), balsalazide (Cay-18680), and olsalazine (Cay-23661). It is formed from these prodrugs by bacterial azoreductases in the intestinal lumen. 5-ASA selectively inhibits COX-2 over COX-1 in isolated human whole blood (IC50s = 61 and 410 µM, respectively). It inhibits hemoglobin- and hydrogen peroxide-induced lipid peroxidation in a cell-free assay (IC50 = 50 µM). 5-ASA (100 µM) also inhibits the synthesis of leukotriene B4 (LTB4, Cay-20110) in isolated human mucosal cells. Formulations containing 5-ASA have been used in the treatment of inflammatory bowel disease (IBD) and ulcerative colitis.Formal Name: 5-amino-2-hydroxy-benzoic acid. CAS Number: 89-57-6. Synonyms: 5-ASA. Molecular Formula: C7H7NO3. Formula Weight: 153.1. Purity: >99%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 1.6 mg/ml, DMSO: 4 mg/ml, PBS (pH 7.2): 1.7 mg/ml. SMILES: Nc1ccc(O)c(c1)C(=O)O. InChi Code: InChI=1S/C7H7NO3/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,9H,8H2,(H,10,11). InChi Key: KBOPZPXVLCULAV-UHFFFAOYSA-N. Origin: Synthetic.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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