4-oxo Docosahexaenoic Acid

4-oxo Docosahexaenoic acid (4-oxo DHA) is a putative metabolite of DHA (Cay-90310) with antiproliferative and PPARgamma agonist activity. It inhibits the growth of several triple negative breast cancer cell lines (MCF-10F, trMCF, bsMCF, MDA-MB-231, and BT549) at 50-100 µM, however it increased proliferation of MCF-7 cells. 4-oxo DHA binds covalently to PPARgamma and activates gene transcription in luciferase reporter assays and in dendritic cells with EC50 values of approximately 8-16 µM.Formal Name: 4-oxo-5E,7Z,10Z,13Z,16Z,19Z-docosahexaenoic acid. CAS Number: 845673-74-7. Synonyms: 4-oxo DHA. Molecular Formula: C22H30O3. Formula Weight: 342.5. Purity: >90%. Formulation: (Request formulation change), A solution in ethanol. Solubility: DMF: 50 mg/ml, DMSO: 50 mg/ml, Ethanol: 50 mg/ml, PBS (pH 7.2): 0.1 mg/ml. lambdamax: 277 nm. SMILES: CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C=C\C(CCC(O)=O)=O. InChi Code: InChI=1S/C22H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-21(23)19-20-22(24)25/h3-4,6-7,9-10,12-13,15-18H,2,5,8,11,14,19-20H2,1H3,(H,24,25)/b4-3-,7-6-,10-9-,13-12-,16-15-,18-17+. InChi Key: UHNUULCIKILOHW-PQVBWYSWSA-N.