231 products were found matching "K08530"!

Rosiglitazone is an agonist of peroxisome proliferator-activated receptor gamma (PPARgamma). It activates PPARgamma1 and PPARgamma2 in reporter assays (EC50s = 30 and 100 nM, respectively). Rosiglitazone selectively activates chimeras containing the ligand-binding domains (LBDs) of PPARgamma over PPARalpha and...

PPARgamma is a ligand-activated transcription factor and member of the nuclear hormone receptor superfamily. It is composed of an N-terminal AF1 domain responsible for ligand-independent transactivation, a DNA-binding domain (DBD), a hinge region, and a C-terminal ligand-binding domain (LBD) and AF2 domain. It is...

The peroxisome proliferator-activated receptor gamma (PPARgamma) is the nuclear receptor responsible for transducing the therapeutic activity of the thiazolidinediones. Thiazolidinediones are a group of structurally related synthetic PPARgamma agonists with antidiabetic actions in vivo. Rosiglitazone (BRL 49653) is...

PPARG(peroxisome proliferator activated receptor gamma) Homo sapiens This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three...

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. PPAR gamma antibody targets peroxisome proliferator activated receptor gamma, a nuclear receptor encoded by the PPARG gene. PPAR gamma functions as a ligand activated transcription factor and plays...

0.5mg/ml if reconstituted with 0.2ml sterile DI water. Pparg (Peroxisome proliferator-activated receptor gamma) is a critical transcription factor that belongs to the nuclear receptor superfamily. It plays a vital role in regulating lipid metabolism, glucose homeostasis, inflammation, and adipocyte differentiation....

Troglitazone is a selective agonist of peroxisome proliferator-activated receptor gamma (PPARgamma, EC50s = 0.78 and 0.55 µM for the mouse and human receptors, respectively, in a transactivation assay). It is selective for PPARgamma over PPARalpha and PPARdelta, at which it is inactive at concentrations up to 10 µM....

This formulation of 15-deoxy-Delta12,14-PGJ2 contains 90-95% of the trans,trans-Delta12,14 isomer, and 5-10% of other double bond isomers which have similar PPARgamma ligand activity (see Catalog No. 18570).Formal Name: 11-oxo-prosta-5Z,9,12E,14E-tetraen-1-oic acid. CAS Number: 87893-55-8. Synonyms:...

Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors belonging to the large family of nuclear hormone receptors. There are three subtypes, PPARalpha, beta/delta, and gamma, which are expressed at variable levels in different tissues. The Cayman Chemical PPARgamma...

This nuclear receptor assay system utilizes proprietary non-human cells engineered to provide constitutive, high-level expression of the human peroxisome proliferator-activated receptor gamma (NR1C3), a ligand-dependent transcription factor commonly referred to as PPARG or PPARgamma. INDIGO's reporter cells include...

Antidiabetic, hypoglycemic agent. Potent and selective peroxisome proliferator-activated receptor gamma (PPAR-gamma) agonist. Potent insulin sensitizing agent binding to the PPAR receptors in fat cells and making the cells more responsive to insulin. Ameliorates insulin resistance. Improves blood pressure and...

Rosiglitazone is an agonist of peroxisome proliferator-activated receptor gamma (PPARgamma). It activates PPARgamma1 and PPARgamma2 in reporter assays (EC50s = 30 and 100 nM, respectively). Rosiglitazone selectively activates chimeras containing the ligand-binding domains (LBDs) of PPARgamma over PPARalpha and...