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Product information "(±)-2-Methyl Arachidonoyl-2'-Fluoroethylamide"
(±)-2-Methyl arachidonoyl-2'-fluoroethylamide (2-Methyl-2'-fluoro AEA) is an analog of anandamide (AEA) in which the alcohol of the ethanolamide group has been removed and replaced with a fluorine atom. This substitution confers considerably increased binding affinity for the CB1 receptor (Ki = 5.7 nM in rat brain). It also confers additional selectivity, in that binding to CB2 is decreased relative to AEA. However, the in vivo activity of 2-fluoro AEA is enhanced much less than the binding affinity, because the analog remains a good substrate for FAAH and is rapidly hydrolyzed by this enzyme. 2-Methyl-2'-fluoro AEA is further modified by the addition of an alpha-methyl group at the C-2 position of arachidonic acid. This substitution confers enhanced metabolic stability. 2-Methyl-2'-fluoro AEA can fully substitute for Delta9-THC in animal self-administration tests, whereas AEA and 2-fluoro AEA cannot.Formal Name: (±)-N-(2-fluoroethyl)-2-methyl-5Z,8Z,11Z,14Z-eicosatetraenamide. CAS Number: 166100-39-6. Synonyms: 2-methyl-2'-fluoro AEA, 2-Methyl-2'-fluoro Anandamide, O-689. Molecular Formula: C23H38FNO. Formula Weight: 363.6. Purity: >95%. Formulation: (Request formulation change), A solution in ethanol. Solubility: DMF: >10 mg/ml, DMSO: >30 mg/ml, Ethanol: >100 mg/ml, Ethanol:PBS (1:2): 8.5 mg/ml, PBS (pH 7.2): <100 µg/ml. SMILES: CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCC(C)C(=O)NCCF. InChi Code: InChI=1S/C23H38FNO/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-22(2)23(26)25-21-20-24/h7-8,10-11,13-14,16-17,22H,3-6,9,12,15,18-21H2,1-2H3,(H,25,26)/b8-7-,11-10-,14-13-,17-16-. InChi Key: HMMNZALKMVCHHZ-ZKWNWVNESA-N.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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