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Product information "17-phenyl trinor Prostaglandin F2alpha"
17-phenyl trinor Prostaglandin F2alpha (17-phenyl trinor PGF2alpha) is a metabolically stable analog of PGF2alpha and is a potent agonist for the FP receptor. It binds to the FP receptor on ovine luteal cells with a relative potency of 756% compared to that of PGF2alpha. At the rat recombinant FP receptor expressed in CHO cells bimatoprost inhibits PGF2alpha binding with a Ki of 1.1 nM. The isopropyl ester of 17-phenyl trinor PGF2alpha ethyl amide is slightly better than PGF2alpha isopropyl ester in reducing the intraocular pressure in the cat eye without any irritation.Formal Name: (5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3S)-3-hydroxy-5-phenyl-1-penten-1-yl]cyclopentyl]-5-heptenoic acid. CAS Number: 38344-08-0. Synonyms: Bimatoprost (free acid), 17-phenyl trinor PGF2alpha. Molecular Formula: C23H32O5. Formula Weight: 388.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: >100 mg/ml, DMSO: >100 mg/ml, Ethanol: >100 mg/ml, PBS (pH 7.2): >800 µg/ml. SMILES: O[C@@H]1[C@H](C/C=C\CCCC(O)=O)[C@@H](/C=C/[C@@H](O)CCC2=CC=CC=C2)[C@H](O)C1. InChi Code: InChI=1S/C23H32O5/c24-18(13-12-17-8-4-3-5-9-17)14-15-20-19(21(25)16-22(20)26)10-6-1-2-7-11-23(27)28/h1,3-6,8-9,14-15,18-22,24-26H,2,7,10-13,16H2,(H,27,28)/b6-1-,15-14+/t18-,19+,20+,21-,22+/m0/s1. InChi Key: YFHHIZGZVLHBQZ-KDACTHKWSA-N.
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