10-Chloroestra-1,4-diene-3,17-dione

10-Chloroestra-1,4-diene-3,17-dione is a sterone agonist of estrogen receptor alpha (ERalpha). It increases reporter gene expression in S. cerevisiae (EC50 = 0.36 nM for the human receptor). It also is an aromatase inhibitor (IC50 = 2.4 µM).Formal Name: 10-chloro-estra-1,4-diene-3,17-dione. CAS Number: 91413-55-7. Synonyms: 10-chloro-1,4-Estradiene. Molecular Formula: C18H21ClO2. Formula Weight: 304.8. Purity: >95%. Formulation: (Request formulation change), A solution in chloroform. Solubility: Chloroform: 10 mg/ml. lambdamax: 241 nm. SMILES: Cl[C@@]12[C@]3([H])[C@](CCC1=CC(C=C2)=O)([H])[C@@]4([H])[C@](CC3)(C(CC4)=O)C. InChi Code: InChI=1S/C18H21ClO2/c1-17-8-7-15-13(14(17)4-5-16(17)21)3-2-11-10-12(20)6-9-18(11,15)19/h6,9-10,13-15H,2-5,7-8H2,1H3/t13-,14-,15-,17-,18+/m0/s1. InChi Key: DMUVDGYKPICJEM-FTAMUGHTSA-N.