JX-401

JX-401 is a potent, reversible inhibitor of the p38alpha isoform of MAP kinase (IC50 = 32 nM). It does not inhibit the p38gamma isoform. JX-401 is effective in mammalian cells, as it blocks the differentiation of myoblasts into myotubes.Formal Name: [2-methoxy-4-(methylthio)phenyl][4-(phenylmethyl)-1-piperidinyl]-methanone. CAS Number: 349087-34-9. Synonyms: p38 MAPK Inhibitor VI, p38 Mitogen-activated Protein Kinase Inhibitor VI. Molecular Formula: C21H25NO2S. Formula Weight: 355.5. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMF:PBS (pH 7.2) (1:5): 0.1 mg/ml, DMSO: 10 mg/ml, Ethanol: 1 mg/ml. lambdamax: 210, 265 nm. SMILES: O=C(C1=CC=C(SC)C=C1OC)N(CC2)CCC2CC3=CC=CC=C3. InChi Code: InChI=1S/C21H25NO2S/c1-24-20-15-18(25-2)8-9-19(20)21(23)22-12-10-17(11-13-22)14-16-6-4-3-5-7-16/h3-9,15,17H,10-14H2,1-2H3. InChi Key: OMGLGPKQUFSRNN-UHFFFAOYSA-N.