327 products were found matching "K04441"!

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by...

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. MAPK14 antibody detects Mitogen-activated protein kinase 14 (also known as p38 alpha), a serine/threonine kinase that plays a pivotal role in cellular responses to stress stimuli and proinflammatory cytokines. Encoded by the MAPK14 gene on...

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. Phospho-p38 (Thr180) antibody detects p38 mitogen activated protein kinase when phosphorylated at threonine 180. The protein is encoded by the MAPK14 gene and is a key member of the stress activated...

Mitogen-activated protein kinases (MAPK) mediate signal transduction from cell surface receptors to the nucleus and are classified into various subtypes. p38 MAPK is activated by environmental stresses and inflammatory cytokines and is critical for normal immune and inflammatory responses as it regulates the...

Potent and cell permeable p38 MAP kinase inhibitor, Apoptosis inducer, Inhibits p38alpha and beta, but not gamma and delta isoforms, Does not inhibit ERK2 or other members of the MAP kinase family or their upstream activators, JNK activator.

A p38delta MAPK inhibitor (IC50 = 620 nM). Formulation: A solid. InChI: InChI=1S/C20H23N5O2/c1-20(2,3)17-13-18(25(4)24-17)23-19(26)22-14-5-7-15(8-6-14)27-16-9-11-21-12-10-16/h5-13H,1-4H3,(H2,22,23,26). InChIKey: MHSLDASSAFCCDO-UHFFFAOYSA-N. SMILES: O=C(NC1=CC=C(OC2=CC=NC=C2)C=C1)NC3=CC(C(C)(C)C)=NN3C

SB-203580 is an inhibitor of p38 MAPK that exhibits immunostimulatory, anticancer, and anti-fibrotic activities. In peripheral blood mononuclear cells, SB-203580 increases secretion of IFN- . In lung epithelial cells, SB-203580 inhibits TGB- 1-induced epithelial-to-mesenchymal transition (EMT). Additionally,...

SB 239063 is a selective p38 MAPK inhibitor (IC50 = 44 nM for recombinant purified p38alpha). It displays greater than 220-fold selectivity for p38 MAPK over ERK, JNK1, and other kinases. SB 239063 has been shown to reduce inflammatory cytokine production in lipopolysaccharide-stimulated human peripheral blood...

Protein function: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress...

SD 169 is a selective ATP competitive inhibitor of the MAP kinases p38alpha (IC50 = 3.2 nM) and p38beta (IC50 = 122 nM). It has no inhibitory effect against a panel of other kinases, including p38gamma MAP kinase, ERK2, JNK-1, and MAPKAPK-2, when tested in vitro at 50 µM. SD 169 is orally active, significantly...

Mitogen-activated protein kinases (MAPKs) mediate signal transduction from cell surface receptors to the nucleus and are classified into various subtypes. p38 MAPK is activated by environmental stresses and inflammatory cytokines and is critical for normal immune and inflammatory responses as it regulates the...

Skepinone-L is an ATP-competitive inhibitor of p38 MAPK isoform p38alpha (IC50s = 5 nM) and p38beta (97% inhibition at 1 µM). It has little effect on a range of other kinases, including p38gamma and p38delta. Skepinone-L dose-dependently blocks the phosphorylation of heat shock protein 27 (HSP27), a p38 MAPK...