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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Zoledronic acid is a third-generation heterocyclic nitrogen-containing bisphosphonate that... more
Product information "Zoledronic Acid (hydrate)"
Zoledronic acid is a third-generation heterocyclic nitrogen-containing bisphosphonate that inhibits the prenylation of GTPases critical to the signaling events related to osteoclast-mediated bone resorption. It has a high affinity for hydroxyapatite (Ki = 3.47 µM) and binds directly to mineralized bone where it decreases bone resorption by inhibiting osteoclast proliferation and inducing osteoclast apoptosis. At µM concentrations, zoledronic acid demonstrates antitumor effects in vitro against breast, prostate, and myeloma cancer cells by inducing cytostasis and prevents bone metastases through its inhibitory effects on adhesion molecules, tumor cell invasion, and angiogenesis. Zoledronic acid has been used in the treatment of osteoporosis, Paget's disease, metastatic bone disease, multiple myeloma, hypercalcemia of malignancy, and skeletal-related events associated with metastatic castrate-resistant prostate cancer.Formal Name: P,P'-[1-hydroxy-2-(1H-imidazol-1-yl)ethylidene]bis-phosphonic acid, monohydrate. CAS Number: 165800-06-6. Molecular Formula: C5H10N2O7P2 . H2O. Formula Weight: 290.1. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: PBS (pH 7.2): 1.6 mg/ml. SMILES: OP(C(O)(P(O)(O)=O)CN1C=NC=C1)(O)=O.O. InChi Code: InChI=1S/C5H10N2O7P2.H2O/c8-5(15(9,10)11,16(12,13)14)3-7-2-1-6-4-7,/h1-2,4,8H,3H2,(H2,9,10,11)(H2,12,13,14),1H2. InChi Key: FUXFIVRTGHOMSO-UHFFFAOYSA-N.
Keywords: | P,P'-[1-hydroxy-2-(1H-imidazol-1-yl)ethylidene]bis-phosphonic acid, monohydrate |
Supplier: | Cayman Chemical |
Supplier-Nr: | 14984 |
Properties
Application: | GTPase prenylation inhibitor, Farnesylpyrophosphate synthetase inhibitor |
MW: | 290.1 D |
Formula: | C5H10N2O7P2 . H2O |
Purity: | >95% |
Format: | Crystalline Solid |
Database Information
CAS : | 165800-06-6| Matching products |
KEGG ID : | K00787 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: -20°C) |
Signal Word: | Warning |
GHS Hazard Pictograms: |
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H Phrases: | H315, H319, H335 |
P Phrases: | P261, P264, P271, P280, P302+352, P304+340, P305+351+338, P312, P321, P332+313, P337+313, P362+364, P403+233, P405, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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