64 products were found matching "K00787"!

Farnesyl pyrophosphate synthase (FPPS, also known as farnesyl diphosphate synthase (FDPS)) is one of the key enzymes involved in the mevalonate pathway and as such is widely expressed. FPPS modulators, specifically FPPS inhibitors, are useful in treating a number of diseases, including bone-related disorders...

This gene encodes an enzyme that catalyzes the production of geranyl pyrophosphate and farnesyl pyrophosphate from isopentenyl pyrophosphate and dimethylallyl pyrophosphate. The resulting product, farnesyl pyrophosphate, is a key intermediate in cholesterol and sterol biosynthesis, a substrate for protein...

Zoledronic acid is a third-generation heterocyclic nitrogen-containing bisphosphonate that inhibits the prenylation of GTPases critical to the signaling events related to osteoclast-mediated bone resorption. It has a high affinity for hydroxyapatite (Ki = 3.47 µM) and binds directly to mineralized bone where it...

Bisphosphonate, FPPS inhibitor.

Pamidronate is an amino bisphosphonate that inhibits farnesyl pyrophosphate (FPP) synthase (IC50s = 0.85 and 0.20 µM in J774 cells and for human recombinant FPP synthase, respectively). In rats, it inhibits bone resorption when used at doses of 16 µmol/kg per day, impairs long bone growth at >40 µmol/kg per day, and...

Ibandronate is a bisphosphonate that has been used in formulations for the treatment of osteoporosis. It binds to hydroxyapatite crystals with an affinity constant of 2.36 µM, inhibiting their growth and bone resorption.Formal Name: P,P'-[1-hydroxy-3-(methylpentylamino)propylidene]bis-phosphonic acid, monosodium...

A pyridinyl biphosphate which inhibits osteoclast-mediated bone resorption.

Description: Alendronate sodium hydrate (MK 217) is a nitrogen-containing bisphosphonate, which is an effective inhibitor of bone resorption. It is utilized for the treatment and prevention of osteoporosis. Target: Transferase. Smiles: C(CC(O)(P(=O)(O)O)P(=O)(O)[O-])CN.O.[Na+].O.O. References: Fisher JE, et al. Proc...

Protein function: Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation....

Zoledronic acid is used as an antiresorptive agent in bone.

Bisphosphonate.

Bisphosphonate, inhibits transfer of farnesyl pyrophosphate.