Z-VRPR-FMK (trifluoroacetate salt)

Z-VRPR-FMK is a selective, irreversible inhibitor of the paracaspase mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1), an endopeptidase that targets BCL10 and reduces NF-kappaB activation in lymphocytes at 12.5 to 75 µM. Other MALT1 substrates that may be affected by Z-VRPR-FMK are TNFAIP3 and CYLD.Formal Name: N-[(phenylmethoxy)carbonyl]-L-valyl-L-arginyl-N-[(1S)-4-[(aminoiminomethyl)amino]-1-(2-fluoroacetyl)butyl]-L-prolinamide, 2,2,2-trifluoroacetate. Synonyms: Z-Val-Arg-Pro-DL-Arg-FMK. Molecular Formula: C31H49FN10O6 . CF3COOH. Formula Weight: 790.8. Purity: >90%. Formulation: (Request formulation change), A solid. Solubility: Water: Soluble. SMILES: O=C(OCC1=CC=CC=C1)N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=N)C(N2CCC[C@H]2C(N[C@H](C(CF)=O)CCCNC(N)=N)=O)=O)=O.FC(F)(C(O)=O)F. InChi Code: InChI=1S/C31H49FN10O6.C2HF3O2/c1-19(2)25(41-31(47)48-18-20-9-4-3-5-10-20)27(45)40-22(12-7-15-38-30(35)36)28(46)42-16-8-13-23(42)26(44)39-21(24(43)17-32)11-6-14-37-29(33)34,3-2(4,5)1(6)7/h3-5,9-10,19,21-23,25H,6-8,11-18H2,1-2H3,(H,39,44)(H,40,45)(H,41. InChi Key: WIPHXOQUHDJLCU-WCFRTMNKSA-N.