XMD8-85

XMD8-85 is an ERK5 inhibitor (IC50 = 87 nM in an enzyme assay). It is selective for ERK5 over tyrosine non-receptor kinase 2 (TNK2, IC50 = 959 nM), but does inhibit the leucine-rich repeat kinase 2 (LRRK2) mutant LRRK2G2019S (IC50 = 26 nM), which has been found in patients with Parkinson's disease. XMD8-85 inhibits EGF-induced ERK5 autophosphorylation in HeLa cells (EC50 = 0.19 µM).Formal Name: 5,11-dihydro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-5,11-dimethyl-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one. CAS Number: 1234479-76-5. Synonyms: ERK5-IN-1. Molecular Formula: C25H29N7O2. Formula Weight: 459.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 10mg/mL, DMSO: 15mg/mL, DMSO:PBS (pH 7.2) (1:1): 0.5mg/mL, Ethanol: 2mg/mL. lambdamax: 291 nm. SMILES: CN1CCN(C2=CC(OC)=C(NC3=NC=C(N(C)C(C(C=CC=C4)=C4N5C)=O)C5=N3)C=C2)CC1. InChi Code: InChI=1S/C25H29N7O2/c1-29-11-13-32(14-12-29)17-9-10-19(22(15-17)34-4)27-25-26-16-21-23(28-25)30(2)20-8-6-5-7-18(20)24(33)31(21)3/h5-10,15-16H,11-14H2,1-4H3,(H,26,27,28). InChi Key: DDTPGANIPBKTNU-UHFFFAOYSA-N.