WIN 18,446

WIN 18,446 is a bis-(dichloroacetyl)-diamine which inhibits aldehyde dehydrogenase 1a2, (IC50 = 300 nM), a testes-specific isoform of the enzyme involved in vitamin A metabolism. In this way, WIN 18,446 suppresses the expression of several genes that are regulated by retinoic acid and are necessary for spermatogenesis. As a result, WIN 18,446 may cause infertility in males.Formal Name: N,N'-1,8-octanediylbis[2,2-dichloro-acetamide]. CAS Number: 1477-57-2. Synonyms: NSC 59354. Molecular Formula: C12H20Cl4N2O2. Formula Weight: 366.1. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMF:PBS (pH 7.2) (1:5): 0.1 mg/ml, DMSO: 5 mg/ml, Ethanol: 0.5 mg/ml. SMILES: O=C(NCCCCCCCCNC(C(Cl)Cl)=O)C(Cl)Cl. InChi Code: InChI=1S/C12H20Cl4N2O2/c13-9(14)11(19)17-7-5-3-1-2-4-6-8-18-12(20)10(15)16/h9-10H,1-8H2,(H,17,19)(H,18,20). InChi Key: FAOMZVDZARKPFJ-UHFFFAOYSA-N.