VS-5584 analog

VS-5584 analog is a dual inhibitor of PI3Kalpha and mammalian target of rapamycin (mTOR, IC50s = 17 and 150 nM, respectively). It is a desmethyl analog of the dual PI3K/mTOR inhibitor VS-5584 (Cay-16294).Formal Name: 5-[9-(1-methylethyl)-2-(4-morpholinyl)-9H-purin-6-yl]-2-pyrimidinamine. CAS Number: 1246535-95-4. Molecular Formula: C16H20N8O. Formula Weight: 340.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Chloroform: 0.5mg/mL. lambdamax: 239, 289, 354 nm. SMILES: CC(C)N(C=N1)C2=C1C(C3=CN=C(N)N=C3)=NC(N4CCOCC4)=N2. InChi Code: InChI=1S/C16H20N8O/c1-10(2)24-9-20-13-12(11-7-18-15(17)19-8-11)21-16(22-14(13)24)23-3-5-25-6-4-23/h7-10H,3-6H2,1-2H3,(H2,17,18,19). InChi Key: NGDDJJKHNGAOCH-UHFFFAOYSA-N.