Vilazodone-d8

Vilazodone-d8 is intended for use as an internal standard for the quantification of vilazodone (Cay-21547) by GC- or LC-MS. Vilazodone is a selective serotonin reuptake inhibitor (SSRI) and a partial agonist of the serotonin (5-HT) receptor subtype 5-HT1A (IC50s = 0.2 and 0.5 nM, respectively). It increases extracellular 5-HT in the rat ventral hippocampus and frontal cortex when administered intraperitoneally at doses of 1 and 3 mg/kg, respectively. Vilazodone (1 mg/kg, i.p.) decreases immobility in the forced swim test in both rats and mice. Formulations containing vilazodone have been used in the treatment of depression.Formal Name: 5-(4-(4-(5-cyano-1H-indol-3-yl)butyl)piperazin-1-yl-2,2,3,3,5,5,6,6-d8)benzofuran-2-carboxamide. CAS Number: 1794789-93-7. Molecular Formula: C26H19D8N5O2. Formula Weight: 449.6. Purity: >99% deuterated forms (d1-d8). Formulation: (Request formulation change), A solid. Solubility: Water: 0.32 mg/ml. SMILES: O=C(N)C(O1)=CC2=C1C=CC(N3C([2H])([2H])C([2H])([2H])N(CCCCC4=CNC5=C4C=C(C#N)C=C5)C([2H])([2H])C3([2H])[2H])=C2. InChi Code: InChI=1S/C26H27N5O2/c27-16-18-4-6-23-22(13-18)19(17-29-23)3-1-2-8-30-9-11-31(12-10-30)21-5-7-24-20(14-21)15-25(33-24)26(28)32/h4-7,13-15,17,29H,1-3,8-12H2,(H2,28,32)/i9D2,10D2,11D2,12D2. InChi Key: SGEGOXDYSFKCPT-PMCMNDOISA-N.