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URB602 is a selective inhibitor of monoacylglycerol lipase (MAGL), exhibiting an IC50 value of 28 µM for the rat brain enzyme. It does not inhibit fatty acid amide hydrolase (FAAH) at concentrations up to 100 µM or other lipid metabolizing enzymes such as diacylglycerol lipase or COX-2. Inhibition of MAGL inhibits 2-arachidonoyl glycerol (Cay-62160) hydrolysis, which is associated with enhanced stress-induced analgesia and may represent a novel drug target in pain and stress management. URB602 (50 µM) also inhibits glucose-stimulated and depolarization-induced insulin secretion in INS-1 cells.Formal Name: N-[1,1'-biphenyl]-3-yl-carbamic acid, cyclohexyl ester. CAS Number: 565460-15-3. Molecular Formula: C19H21NO2. Formula Weight: 295.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2)(1:1): .25 mg/ml, Ethanol: 10 mg/ml. lambdamax: 236 nm. SMILES: O=C(OC1CCCCC1)Nc1cccc(c1)c1ccccc1. InChi Code: InChI=1S/C19H21NO2/c21-19(22-18-12-5-2-6-13-18)20-17-11-7-10-16(14-17)15-8-3-1-4-9-15/h1,3-4,7-11,14,18H,2,5-6,12-13H2,(H,20,21). InChi Key: HHVUFQYJOSFTEH-UHFFFAOYSA-N.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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