UPF-1069

The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis, particularly in response to reactive oxygen and nitrogen species. UPF-1069 is a PARP inhibitor that demonstrates a modest preference for PARP2 over PARP1 (IC50s = 0.3 and 8 µM, respectively). In rat models of post-ischemic brain damage, it has been shown to increase cell death in hippocampal slice cultures in a model characterized by loss of neurons through a caspase-dependent, apoptosis-like process but to be protective of cortical neurons in a model characterized by a necrosis-like process.Formal Name: 5-(2-oxo-2-phenylethoxy)-1(2H)-isoquinolinone. CAS Number: 1048371-03-4. Synonyms: GKT237841. Molecular Formula: C17H13NO3. Formula Weight: 279.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 0.5 mg/mL, DMSO: 0.5 mg/mL, Ethanol: 0.3 mg/mL. lambdamax: 240, 280, 291, 330, 345 nm. SMILES: O=C1NC=CC2=C(OCC(C3=CC=CC=C3)=O)C=CC=C21. InChi Code: InChI=1S/C17H13NO3/c19-15(12-5-2-1-3-6-12)11-21-16-8-4-7-14-13(16)9-10-18-17(14)20/h1-10H,11H2,(H,18,20). InChi Key: JJWMRRNGWSITSQ-UHFFFAOYSA-N.