TVB-2640

TVB-2640 is an inhibitor of fatty acid synthase (FASN, IC50 = 0.5 µM). It inhibits infection of an infectious-clone-derived severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reporter virus in HEK293T cells expressing human angiotensin-converting enzyme 2 (ACE2, EC50 = 4 nM).Formal Name: 4-[1-[4-cyclobutyl-2-methyl-5-(3-methyl-1H-1,2,4-triazol-5-yl)benzoyl]-4-piperidinyl]-benzonitrile. CAS Number: 1399177-37-7. Synonyms: Denifanstat, Fatty Acid Synthase Inhibitor 2, FASN-IN-2. Molecular Formula: C27H29N5O. Formula Weight: 439.6. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble. lambdamax: 231 nm. SMILES: N#CC1=CC=C(C2CCN(CC2)C(C3=CC(C4=NN=C(C)N4[H])=C(C5CCC5)C=C3C)=O)C=C1. InChi Code: InChI=1S/C27H29N5O/c1-17-14-24(22-4-3-5-22)25(26-29-18(2)30-31-26)15-23(17)27(33)32-12-10-21(11-13-32)20-8-6-19(16-28)7-9-20/h6-9,14-15,21-22H,3-5,10-13H2,1-2H3,(H,29,30,31). InChi Key: BBGOSBDSLYHMRA-UHFFFAOYSA-N.