87 products were found matching "K00665"!

Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group...

The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha...

Malonyl coenzyme A is a coenzyme A (CoA, Cay-16147) derivative that is used in fatty acid and polyketide synthesis and in the transport of alpha-ketoglutarate across the mitochondrial membrane. Malonyl-CoA is formed by acetyl-CoA carboxylase-mediated carboxylation of acetyl-CoA (Cay-16160). Fatty acid synthase...

GSK2194069 is an inhibitor of fatty acid synthase (FASN) with an IC50 value of 7.7 nM in an assay detecting released CoA. It is a competitive inhibitor that is selective for the KR domain over the KS domain of FASN, with IC50 values of 29 and >10,000 nM, respectively, in vitro. GSK2194069 decreases incorporation of...

Protein function: Fatty acid synthetase catalyzes the formation of long- chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities and an acyl carrier protein. [The UniProt Consortium]

TVB-2640 is an inhibitor of fatty acid synthase (FASN, IC50 = 0.5 µM). It inhibits infection of an infectious-clone-derived severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reporter virus in HEK293T cells expressing human angiotensin-converting enzyme 2 (ACE2, EC50 = 4 nM).Formal Name:...

C75 is stable fatty acid synthase (FASN) inhibitor that when administered in racemic form leads to profound weight loss and feeding inhibition in both high-fat diet wild type obese and leptin-deficient ob/ob mice. C75 is also cytotoxic to many human cancer cell lines, an effect believed to be mediated by the...

UCM05 is an inhibitor of fatty acid synthase that strongly suppresses the growth of human breast cancer cell lines (IC50 = 21 µM for SK-BR-3 cells). It does not alter carnitine palmitoyltransferase 1 activity or induce weight loss in mice. UCM05 can reduce cleavage of poly(ADP-ribose) polymerase, phosphorylation of...

Protein function: Fatty acid synthetase catalyzes the formation of long- chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities and an acyl carrier protein. [The UniProt Consortium]

Icaritin is a flavonoid first isolated from the Chinese herb H. epimedii that demonstrates anticancer activity against a variety of tumor cell lines. It has been shown to inhibit fatty acid synthase, reducing IGF-1-induced activation of STAT3 in several melanoma cell lines.Formal Name:...

TVB-3166 is an inhibitor of fatty acid synthase (FASN, IC50 = 0.042 µM). It inhibits the biosynthesis of palmitate (Cay-10010279) in Calu-6 non-small cell lung cancer (NSCLC) cells and MRC-5 lung fibroblasts in a concentration-dependent manner. TVB-3166 (0.2 µM) induces apoptosis in Calu-6, as well as 22Rv1 prostate...

White to off-white powder. Soluble in DMSO or methanol. Insoluble in water. Anticancer compound. Shown to inhibit progression of prostate cancer cells, Anti-obesity agent, 3T3-L1 adipocyte differentiation and FASN expression inhibitor.