Tiplaxtinin

Tiplaxtinin is an inhibitor of plasminogen activator inhibitor 1 (PAI-1, IC50 = 2.7 µM for the human enzyme). It inhibits differentiation of human adipocytes when used at a concentration of 5 µM. Tiplaxtinin (5 and 20 mg/kg) reduces tumor growth and microvessel density in a T24 bladder cancer mouse xenograft model. It prevents carotid artery occlusion, increases the time to occlusive thrombosis, and decreases the thrombus size in a rat model of ferric chloride-induced arterial thrombosis when administered at a dose of 1 mg/kg.Formal Name: alpha-oxo-1-(phenylmethyl)-5-[4-(trifluoromethoxy)phenyl]-1H-indole-3-acetic acid. CAS Number: 393105-53-8. Synonyms: PAI-039, Tiplasinin. Molecular Formula: C24H16F3NO4. Formula Weight: 439.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 33 mg/ml, DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml, DMSO: 25 mg/ml, Ethanol: 14 mg/ml. lambdamax: 252, 328 nm. SMILES: O=C(C(O)=O)C1=CN(CC2=CC=CC=C2)C3=CC=C(C4=CC=C(OC(F)(F)F)C=C4)C=C31. InChi Code: InChI=1S/C24H16F3NO4/c25-24(26,27)32-18-9-6-16(7-10-18)17-8-11-21-19(12-17)20(22(29)23(30)31)14-28(21)13-15-4-2-1-3-5-15/h1-12,14H,13H2,(H,30,31). InChi Key: ODXQFEWQSHNQNI-UHFFFAOYSA-N.